Artículos de revistas
Structure-activity relationship of 1-desamino-8-D-arginine vasopressin as an antiproliferative agent on human vasopressin V2 receptor-expressing cancer cells
Fecha
2014-04Registro en:
Pastrian, María Belén; Guzmán, Fanny; Garona, Juan; Pifano, Marina; Ripoll, Giselle Vanina; et al.; Structure-activity relationship of 1-desamino-8-D-arginine vasopressin as an antiproliferative agent on human vasopressin V2 receptor-expressing cancer cells; Spandidos Publications; Molecular Medicine Reports; 9; 6; 4-2014; 2568-2572
1791-2997
1791-3004
CONICET Digital
CONICET
Autor
Pastrian, María Belén
Guzmán, Fanny
Garona, Juan
Pifano, Marina
Ripoll, Giselle Vanina
Cascone, Osvaldo
Ciccia, Graciela Noemi
Albericio Palomera, Fernando
Gomez, Daniel Eduardo
Alonso, Daniel Fernando
Iannucci, Nancy Beatriz
Resumen
The synthetic nonapeptide 1-desamino-8-D-arginine vasopressin (dDAVP) can reduce tumor cell growth through agonist action on the vasopressin V2 receptor. A structure-antiproliferative activity relationship analysis of dDAVP was performed using the alanine scanning technique on the aggressive MDA-MB-231 human breast carcinoma cell line. The results from this analysis demonstrated that the amino acids located at the loop of dDAVP are important for the antiproliferative activity of dDAVP, highlighting the key role of the N-terminal region of the peptide in the interaction with the tumor cell surface receptor. The findings from this study present novel strategies for designing improved compounds with enhanced stability for cancer therapy.