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Avaliação da atividade antibacteriana, citotóxica e nuclease química de complexos triazenidos de platina (II)
(Universidade Federal de Santa MariaBRFarmacologiaUFSMPrograma de Pós-Graduação em Ciências Farmacêuticas, 2015-04-30)
Despite the large number of antimicrobials and anti-tumor drugs, therapeutic arsenal is limited due to the emergence of bacterial resistance mechanisms and refractoriness, besides the toxicity of certain drugs. This has ...
Quantification of Xylella fastidiosa from citrus trees by real-time polymerase chain reaction assay
(Amer Phytopathological SocSt PaulEUA, 2002)
Avaliação da estabilidade físico-química e biológica de plasmídeos com potencial biotecnológico
(BrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM BIOQUÍMICA, 2017-05-29)
Studies involving plasmid stability have started for at least two decades and have been growing in recent years, since pDNAs have had enormous potential as vectors in gene therapy, however the therapeutic use of these ...
Identificação de nucleases produzidas por fungos do complexo de espécies paracoccidioides spp.
(Universidade Estadual Paulista (Unesp), 2020-08-28)
A paracoccidioidomicose é uma micose sistêmica cujos agentes etiológicos são os fungos do complexo de espécies Paracoccidioides spp. As espécies conhecidas até o momento receberam os nomes de Paracoccidioides brasiliensis ...
Assessment of a quantitative 5' nuclease real-time polymerase chain reaction using the nicotinamide adenine dinucleotide dehydrogenase gamma subunit (nuoG) for Bartonella species in domiciled and stray cats in Brazil
(SAGE Publications, 2015)
The objective of this study was to develop a quantitative 5' nuclease real-time polymerase chain reaction (PCR) assay to diagnose infections caused by Bartonella species. Between January and April 2013 whole blood samples ...
Assessment of a quantitative 5′ nuclease real-time polymerase chain reaction using groEL gene for Ehrlichia and Anaplasma species in rodents in Brazil
(2017-06-01)
New genotypes of Anaplasmataceae agents have been detected in wild carnivores, birds and deer in Brazil. The present work aimed to investigate the presence of Ehrlichia and Anaplasma species in rodents sampled in Brazil. ...
Inhibition of aac(6')-Ib-mediated amikacin resistance by nuclease-resistant external guide sequences in bacteria
(National Academy of Sciences, 2009-07)
Inhibition of bacterial gene expression by RNase P-directed cleavage is a promising strategy for the development of antibiotics and pharmacological agents that prevent expression of antibiotic resistance. The rise in ...
Efficient edition of the bovine PRNP prion gene in somatic cells and IVF embryos using the CRISPR/Cas9 system
(Elsevier Science Inc, 2016-11)
The recently developed engineered nucleases, such as zinc-finger nucleases, transcription activator-like effector nucleases, and clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated nuclease ...
Development and validation of a high performance liquid 4 chromatography method for oligodeoxynucleotides determination 5 in a novel coagel-based formulation
(Elsevier, 2015-03)
The therapeutic benefit of phosphorothioate oligodeoxynucleotides (PS-ODN) containing immune stimulatory sequences has been demonstrated in animal models of cancer and infection. Several tools are available for the ...