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Synthesis of benzo[b]thiophene carboxamides connected to 4-arylpiperazines through a benzylic spacer: Potential Ligands with 5-HT1A binding affinity
(TAYLOR & FRANCIS INC, 2007)
New benzothiophene arylpiperazine derivatives 8 (a-f) were synthesized as potential serotoninergic agents with 5-HT1A receptor affinity. Preparation of the derivatives was performed by treating N-[2-(chloromethyl)phenyl] ...
Synthesis of benzo[b]thiophene carboxamides connected to 4-arylpiperazines through a benzylic spacer: Potential Ligands with 5-HT1A binding affinity
(TAYLOR & FRANCIS INC, 2007)
New benzothiophene arylpiperazine derivatives 8 (a-f) were synthesized as potential serotoninergic agents with 5-HT1A receptor affinity. Preparation of the derivatives was performed by treating N-[2-(chloromethyl)phenyl] ...
Synthesis of 2-benzothienyl carbonyl 4-arylpiperazines as novel delavirdine analogs
(TAYLOR & FRANCIS INC, 2007)
A novel series of 2-benzothienyl carbonyl arylpiperazines (6a-f) was synthesized as potential HIV nonnucleoside reverse transcriptase inhibitors (NNRTIs). Preparation of the derivatives was performed by reacting benzo[b]thiophene ...
Synthesis of 4-arylpiperazine derivatives of moclobemide: Potential antidepressants with a dual mode of action
(MARCEL DEKKER INC, 2004-07)
We report here the synthesis of substituted 4-chloro-N-[3-oxo-3-(4-aryl-1-piperazinyl)-propyl] benzamides (5-9), as potential new antidepressants, incorporating in a single molecule structural moieties related to a dual ...
Synthesis, Docking Studies and Biological Evaluation of Benzobthiophen-2-yl-3-(4-arylpiperazin-1-yl)-propan-1-one Derivatives on 5-HT1A Serotonin Receptors
(2012)
A series of novel benzobthiophen-2-yl-3-(4-arylpiperazin-1-yl)-propan-1-one
derivatives 6a–f, 7a–f and their corresponding alcohols 8a–f were synthesized and
evaluated for their affinity towards 5-HT1A receptors. The ...
A chemometric study of the 5-HT1A receptor affinities presented by arylpiperazine compounds
(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2008)
Arylpiperazine compounds are promising 5-HT1A receptor ligands that can contribute for accelerating the onset of therapeutic effect of selective serotonin reuptake inhibitors. In the present work, the chemometric methods ...
Solvent-free microwave synthesis of 3-(4-benzo[b]thiophene-2-carbonyl)-1-piperazinyl-1-benzo[b]thiophen-2-yl-1-propanones. New hetero bis-ligands with potential 5-HT1A serotonergic activity
(PERGAMON-ELSEVIER SCIENCE LTD, 2008)
A novel series of 2-benzothiophenealkylpiperazine derivatives 11 (a-d) with potential affinity at 5-HT1A serotonin receptors have been synthesized via solvent-free, microwave-promoted Michael addition of benzo[b]thiophene ...
QSAR on aryl-piperazine derivatives with activity on malaria
(Elsevier Science, 2012-01-15)
In this work we offer linear regression models on a set of aryl-piperazine derivatives that are obtained by exploring a pool containing 1497 Dragon molecular descriptors, in order to establish the best relationships linking ...
Two-dimensional QSAR studies on arylpiperazines as high-affinity 5-HT(1A) receptor ligands
(BENTHAM SCIENCE PUBL LTD, 2008)
5-HT(1A) receptor plays an important role in the delayed onset of antidepressant action of a class of selective serotonin reuptake inhibitors. Moreover, 5-HT(1A) receptor levels have been shown to be altered in patients ...
Synthesis, docking studies and biological evaluation of benzo[b]thiophen-2-yl-3-(4-arylpiperazin-1-yl)-propan-1-one derivatives on 5-HT 1A serotonin receptors
(2012)
A series of novel benzo[b]thiophen-2-yl-3-(4-arylpiperazin-1-yl)-propan-1- one derivatives 6a-f, 7a-f and their corresponding alcohols 8a-f were synthesized and evaluated for their affinity towards 5-HT 1A receptors. The ...