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Decrease of ERK/MAPK overactivation in prefrontal cortex reverses early memory deficit in a mouse model of Alzheimer's disease
(Ios Press, 2013-11)
Alzheimer's disease (AD) can be considered as a disease of memory in its initial clinical stages. Amyloid-β (Aβ) peptide accumulation is central to the disease initiation leading later to intracellular neurofibrillary ...
APP/Go protein Gβγ-complex signaling mediates Aβ degeneration and cognitive impairment in Alzheimer's disease models
(Elsevier Science Inc, 2018-04-20)
Deposition of amyloid-β (Aβ), the proteolytic product of the amyloid precursor protein (APP), might cause neurodegeneration and cognitive decline in Alzheimer's disease (AD). However, the direct involvement of APP in the ...
Efeitos do análogo do hormônio tireoideano seletivo para o TRbeta, Sob-AM2, e do T3 no desenvolvimento das alterações neuropatológicas características da Doença de Alzheimer, na função cognitiva e no comportamento de camundongos transgênicos 3xTg-AD
(Universidade Federal de São Paulo, 2022-02-24)
Os hormônios tireoideanos desempenham importante papel fisiológico na homeostase do Sistema Nervoso Central. Em indivíduos adultos, o hipotireoidismo está associado a uma série de disfunções no Sistema Nervoso Central, ...
BACE1 RNAi restores the composition of phosphatidylethanolamine-derivates related to memory improvement in aged 3xTg-AD mice
(Frontiers Research FoundationGrupo de Neurociencias de AntioquiaSuiza, 2017)
[Morphological analysis of the hippocampal region associated with an innate behaviour task in the transgenic mouse model (3xTg-AD) for Alzheimer disease]
(2013)
INTRODUCTION: Different animal models for Alzheimer disease (AD) have been designed to support the hypothesis that the neurodegeneration (loss of neurons and synapses with reactive gliosis) associated with Abeta and tau ...
Morphological analysis of the hippocampal region associated with an innate behaviour task in the transgenic mouse model (3xTg-AD) for Alzheimer disease
(2013)
Introduction: Different animal models for Alzheimer disease (AD) have been designed to support the hypothesis that the neurodegeneration (loss of neurons and synapses with reactive gliosis) associated with A? and tau ...
[Morphological analysis of the hippocampal region associated with an innate behaviour task in the transgenic mouse model (3xTg-AD) for Alzheimer disease]
(2013)
INTRODUCTION: Different animal models for Alzheimer disease (AD) have been designed to support the hypothesis that the neurodegeneration (loss of neurons and synapses with reactive gliosis) associated with Abeta and tau ...
Morphological analysis of the hippocampal region associated with an innate behaviour task in the transgenic mouse model (3xTg-AD) for Alzheimer disease
(2013)
Introduction: Different animal models for Alzheimer disease (AD) have been designed to support the hypothesis that the neurodegeneration (loss of neurons and synapses with reactive gliosis) associated with Aβ and tau ...