Now showing items 1-10 of 29
Autophagy as a Neuroprotective Mechanism Against 3-Nitropropionic Acid-Induced Murine Astrocyte Cell Death
Huntington's disease (HD) is a genetic neurodegenerative disorder that is characterized by severe striatal atrophy with extensive neuronal loss and gliosis. Although the molecular mechanism is not well understood, experimental ...
Mitochondrial calcium, oxidative stress and apoptosis in a neurodegenerative disease model induced by 3-nitropropionic acid
(Blackwell Publishing Ltd, 2004-03-01)
Intracellular calcium homeostasis is important for cell survival. However, increase in mitochondrial calcium (Ca-m(2+)) induces opening of permeability transition pore (PTP), mitochondrial dysfunction and apoptosis. Since ...
Neurotoxins and neurotoxicity mechanisms. An overview
(Springer New York LLC, 2006)
Neurotoxlns represent unique chemical tools, providing a means to 1) gain insight into cellular mechanisms of apopotosis and necrosis, 2) achieve a morphological template for studies otherwise unattainable, 3) specifically ...
Lactate dehydrogenase activity is inhibited by methylmalonate in vitro
(Springer/plenum PublishersNew YorkEUA, 2006)
Astrocytes from cortex and striatum show differential responses to mitochondrial toxin and BDNF: Implications for protection of striatal neurons expressing mutant huntingtin
(BioMed Central, 2020-10)
Background: Evidence shows significant heterogeneity in astrocyte gene expression and function. We previously demonstrated that brain-derived neurotrophic factor (BDNF) exerts protective effects on whole brain primary ...
Mitochondrial permeability transition in neuronal damage promoted by Ca2+ and respiratory chain complex II inhibition
(Blackwell Publishing LtdOxfordInglaterra, 2004)
Melanocortin 4 receptor activation protects striatal neurons and glial cells from 3-nitropropionic acid toxicity
(Academic Press Inc Elsevier Science, 2019-01)
α-Melanocyte stimulating hormone (α-MSH) is a melanocortin which exerts potent anti-inflammatory and anti-apoptotic effects. Melanocortin 4 receptors (MC4R) are abundantly expressed in the brain and we previously demonstrated ...
Partial resistance to malonate-induced striatal cell death in transgenic mouse models of Huntington's disease is dependent on age and CAG repeat length
(Blackwell Science LtdOxfordInglaterra, 2001)