Resenha
Effects of 3-nitropropionic acid administration on memory and hippocampal lipid peroxidation in sleep-deprived mice
Fecha
2007-01-30Registro en:
Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 31, n. 1, p. 65-70, 2007.
0278-5846
10.1016/j.pnpbp.2006.06.019
WOS:000243738000008
Autor
Silva, Regina H.
Abilio, Vanessa C.
Kameda, Sonia R.
Takatsu-Coleman, Andre L.
Carvalho, Rita C.
Ribeiro, Rosana de A.
Tufik, Sergio [UNIFESP]
Frussa-Filho, Roberto
Institución
Resumen
Numerous studies have described memory deficits following sleep deprivation. There is also evidence that the absence of sleep increases brain oxidative stress. the present study investigates the effects of a pro-oxidant agent-3-nitropropionic acid (3-NP)-on hippocampal oxidative stress and passive avoidance performance of sleep-deprived mice. Mice were repeatedly treated i.p. with saline or 5 or 15 mg/kg 3-NP and sleep-deprived for 24 h by the multiple platform method-groups of 4-5 animals placed in water tanks, containing 12 platforms (3 cm in diameter) surrounded by water up to 1 cm beneath the surface or kept in their home cage (control groups). the results showed that: (1) neither a 24 h sleep deprivation period nor 3-NP repeated treatment alone were able to induce memory deficits and increased hippocampal lipid peroxidation; (2) this same protocol of sleep deprivation, combined with 15 mg/kg 3-NP repeated treatment, induced memory deficits and an increase in hippocampal lipid peroxidation. the results support the involvement of hippocampal oxidative stress in the memory deficits induced by sleep deprivation and the hypothesis that normal sleep would prevent oxidative stress. (c) 2006 Elsevier Inc. All rights reserved.