The distribution of two-pore-domain (2P-domain) K+ channels of the TREK subfamily was studied using immunocytochemistry in the peripheral vestibular system of mouse and rat. Using RT-PCR, the mRNA for TREK-1, but not for ...

K+ channels in the inner ear regulate the secretion and homeostasis of K+, i.e. the flux of K+ ions required to ensure good mechanosensory transduction. We studied the expression and cellular localization of TWIK-1 and ...

Two-pore domain potassium (K2P) channels are responsible for maintaining the background conductance essential to the resting membrane potential. K2P channels assemble as dimers containing two pore-forming domains and ...

K+ channels allow the selective transfer of K+ ions inside or outside of the cell. Within this family we find K2P channels, with four transmembrane segments and two pore domains per subunit to form a functional dimer. These ...

Two-pore domain potassium (K-2P) channels are membrane proteins widely identified in mammals, plants, and other organisms. A functional channel is a dimer with each subunit comprising two pore-forming loops and four ...

Two-­‐pore domain potassium (K2P) channels underlie the background K+ currents in mammalian cells. They can be segregated into six subfamilies based on their structure and functional properties. The acid-­‐ sensitive TAS ...