Buscar
Mostrando ítems 1-10 de 23
Stable and high-level production of recombinant Factor IX in human hepatic cell line
(WILEY-BLACKWELL, 2011)
Hemophilia B is a genetic disease of the coagulation system that affects one in 30,000 males worldwide. Recombinant human Factor IX (rhFIX) has been used for hemophilia B treatment, but the amount of active protein generated ...
Integration pattern of HIV-1 based lentiviral vector carrying recombinant coagulation factor VIII in Sk-Hep and 293T cells
(SPRINGER, 2011)
293T and Sk-Hep-1 cells were transduced with a replication-defective self-inactivating HIV-1 derived vector carrying FVIII cDNA. The genomic DNA was sequenced to reveal LTR/human genome junctions and integration sites. One ...
Annexin 1: differential expression in tumor and mast cells in human larynx cancer
(Wiley-Blackwell, 2014)
AAV Gene Therapy for Alcoholism: Inhibition of Mitochondrial Aldehyde Dehydrogenase Enzyme Expression in Hepatoma Cells.Aav gene therapy for alcoholism: inhibitión of mitochondrial aldehyde dehydrogenase enzyme expressión in hepatoma cells.
(2017)
Alcoholism is a serious socio-economic problem. The cost associated with alcohol abuse
for the Chilean economy is estimated at USD$1300 million, in the USA alcoholism costs
$185 billion mainly due to lost productivity, ...
Transfection of bovine fetal fibroblast with polyethylenimine (PEI) nanoparticles: effect of particle size and presence of fetal bovine serum on transgene delivery and cytotoxicity
(Springer, 2017-08)
The development of efficient transfection protocols for livestock cells is crucial for implementation of cell-based transgenic methods to produce genetically modified animals. We synthetized fully deacylated linear 22, 87 ...
AAV gene therapy for alcoholism: inhibition of mitochondrial aldehyde dehydrogenase enzyme expression in hepatoma cells
(Mary Ann Liebert, Inc., 2017)
Most ethanol is broken down in the liver in two steps by alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH2) enzymes, which metabolize down ethanol into acetaldehyde and then acetate. Some individuals from the ...
Relação estrutura-atividade do peptídeo sintético Lunatina-1 e seus derivados na citotoxicidade de diferentes linhagens celulares
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em Bioquímica e ImunologiaUFMG, 2018-08-17)
Lunatin-1 is a 13mer peptide isolated from the peruvian scorpion Hadruroides lunatus
venom. In this study, the synthetic peptide exhibited activity against different tumor cell
lines, such as HL60, MDA-MB-231 e MCF-7. ...
Evaluación in vitro de la toxicidad de alda-1, un compuesto experimental para el tratamiento del alcoholismo
(Universidad de Chile, 2022)
El alcohol es una sustancia psicoactiva con propiedades tóxicas y productoras de dependencia. La OMS estima que 3 millones de muertes anuales son atribuibles al consumo de alcohol. El tratamiento farmacológico actual del ...