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APP signaling in Alzheimer's disease
(Impact Journals, 2018-11)
A large body of evidence supports the Amyloid β (Aβ) cascade hypothesis underlying neurodegeneration in Alzheimer’s disease (AD). Although the mechanism by which Aβ induces neuronal dysfunction and death is still matter ...
Vitamin E but not 17β-estradiol protects against vascular toxicity induced by β-amyloid wild type and the dutch amyloid variant
(2002)
Amyloid β-peptide (Aβ) fibril deposition on cerebral vessels produces cerebral amyloid angiopathy that appears in the majority of Alzheimer's disease patients. An early onset of a cerebral amyloid angiopathy variant called ...
Small Molecule Inhibitors of Lysozyme Amyloid Aggregation
(Springer, 2020)
Immunosensor for diagnosis of Alzheimer disease using amyloid-β 1-40 peptide and silk fibroin thin films
(2016-11-01)
Layer-by-Layer (LbL) films containing silk fibroin (SF) and the 40 aminoacid-long amyloid-β peptide (Aβ1-40) were prepared with the purpose of developing a new prototype of an electrochemical immunosensor. The film showed ...
β-amyloid oligomers affect the structure and function of the postsynaptic region: Role of the Wnt signaling pathway
(2008)
Background: Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the growing population of elderly people. Synaptic dysfunction is an early manifestation of AD. The cellular mechanism by which β-amyloid ...
Securinine derivatives as potential anti-amyloid therapeutic approach
(Bentham Science Publishers B.V., 2017)
In silico evidence of direct interaction between statins and β-amyloid
(Wiley-Liss Inc., 2019)
Distinct conformational states of the Alzheimer β-amyloid peptide can be detected by high-pressure NMR spectroscopy
(Wiley-VCH VerlagWeinheim, 2013-08)
Folding under pressure: High-pressure NMR spectroscopy detects three different conformational states of the Aβ-peptide in solution: a compactly folded state 1, a partially folded state 2′, and a random-coil like state 2′′ ...