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Recruitment of integrin α ν β 3 to integrin α 5 β 1 -induced clusters enables focal adhesion maturation and cell spreading
(Company of Biologists, 2019-11)
The major fibronectin (FN)-binding α5β1 and αvβ3 integrins exhibit cooperativity during cell adhesion, migration and mechanosensing, through mechanisms that are not yet fully resolved. Exploiting mechanically tunable ...
Integrin αvβ3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells
(American Society of Hematology, 2015-01)
The interaction of lymphoid tumor cells with components of the extracellular matrix via integrin αvβ3 allows tumor survival and growth. This integrin was demonstrated to be the membrane receptor for thyroid hormones (THs) ...
Triiodothyronine activated extranuclear pathways upregulate adiponectin and leptin in murine adipocytes
(2020-03-01)
Adiponectin and leptin, important for metabolic regulation, are synthesized and secreted by adipose tissue and are influenced by triiodothyronine (T3) that activates the MAPK/ERK and integrin αVβ3 pathways, modulating gene ...
Astrocyte-to-neuron communication through integrin-engaged Thy-1/CBP/Csk/Src complex triggers neurite retraction via the RhoA/ROCK pathway
(Elsevier B.V., 2017)
© 2016 Elsevier B.V. Two key proteins for cellular communication between astrocytes and neurons are αvβ3 integrin and the receptor Thy-1. Binding of these molecules in the same (cis) or on adjacent (trans) cellular membranes ...
Single-molecule measurements of the effect of force on Thy-1/αvβ3-integrin interaction using nonpurified proteins
(American Society for Cell Biology, 2018)
Thy-1 and αvβ3 integrin mediate bidirectional cell-to-cell communication between neurons and astrocytes. Thy-1/αvβ3 interactions stimulate astrocyte migration and the
retraction of neuronal prolongations, both processes ...
Nongenomic actions of thyroid hormones regulate the growth and angiogenesis of T cell lymphomas
(Frontiers Media S.A., 2019-02)
T-cell lymphomas (TCL) are a heterogeneous group of aggressive clinical lymphoproliferative disorders with considerable clinical, morphological, immunophenotypic, and genetic variation, including ∼10–15% of all lymphoid ...
Contractility through the mechanosensors αVβ3 Integrin/Syndecan-4 in astrocytes
(Universidad de Chile, 2020)
Las lesiones del sistema nervioso central cambian química y físicamente el entorno de las neuronas y las células gliales mediante la liberación de moléculas proinflamatorias y proteínas de la matriz extracelular, generando ...
Thyroid hormones and their membrane receptors as therapeutic targets for T cell lymphomas
(Elsevier, 2016-07)
Thyroid hormones (THs) are important regulators of metabolism, differentiation and cell proliferation. They can modify the physiology of human and murine T cell lymphomas (TCL). These effects involve genomic mechanisms, ...
Bloqueio da integrina αvβ3 inibe apoptose e induz autofagia em células tumorais de cancêr de mama
(Universidade Federal de São CarlosUFSCarPrograma Interinstitucional de Pós-Graduação em Ciências Fisiológicas - PIPGCFCâmpus São Carlos, 2018-12-17)
Integrins are key receptors that mediate cell adhesion to the extracellular matrix (ECM) and regulate cell behavior including cell migration. Particularly, αvβ3 integrin, the vitronectin receptor, plays a key role in both ...
Estudo do papel da integrina αvβ3 de vesículas extracelulares de células tumorais de mama sobre células endoteliais em modelo de co-cultura
(Universidade Federal de São CarlosUFSCarCâmpus São CarlosFisioterapia - Fisio, 2021-11-30)
Breast cancer is one of the most worrisome diseases because of its high rate of morbidity and mortality. It can be caused by different types of tumors, most of which are treated with hormone therapy. However, triple negative ...