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Tricyclic antidepressants inhibit hippocampal α7* and α9α10 nicotinic acetylcholine receptors by different mechanisms
(Pergamon-Elsevier Science Ltd, 2018-07)
The activity of tricyclic antidepressants (TCAs) at α7 and α9α10 nicotinic acetylcholine receptors (AChRs) as well as at hippocampal α7-containing (i.e., α7*) AChRs is determined by using Ca 2+ influx and electrophysiological ...
Antiplatelet activity and TNF-α release inhibition of phthalimide derivatives useful to treat sickle cell anemia
(2019-08-01)
Sickle Cell Anemia (SCA) is one of the most prevalent hereditary hematological diseases worldwide. The disease is characterized by chronic inflammation, hypercoagulable state, and pro-thrombotic profile, which lead the ...
DNA Inhibits the Catalytic Activity of the α Subunit of Protein Kinase CK2
(1995)
The recombinant α subunit of protein kinase CK2 (casein kinase 2) from Xenopus laevis is inhibited by the addition of single stranded or double stranded DNA. This inhibition is competitive with the casein substrate, having ...
Inhibition of nitric oxide and tumour necrosis factor-α production in peritoneal macrophages by aspergillus nidulans melanin
(2013-12-01)
The naturally occurring pigment, melanin is found in organisms of all phylogenetic kingdoms, including fungi, and exhibits a wide range of biological activities. Our objective was to investigate the effects of melanin ...
α-RgIA: A novel conotoxin that specifically and potently blocks the α9α10 nAChR
(American Chemical Society, 2006-02)
The α9 and α10 nicotinic acetylcholine receptor (nAChR) subunits assemble to form the α9α10 nAChR subtype. This receptor is believed to mediate cholinergic synaptic transmission between efferent olivocochlear fibers and ...
Síntese e avaliação da atividade herbicida de compostos do tipo 3-alquil- 1α,2α,4α,5α-tetrametil-6,7-exo-isopropilidenodioxi-8-oxabiciclo[3.2.1]oct-2-enoSynthesis and evaluation of herbicide activity from compounds of the 3- alkyl-1α,2α,4α,5α-tetramethyl-6,7-exo-isopropylidenodioxy-8-oxabicyclo[3.2.1] oct-2-ene type
(Universidade Federal de Viçosa, 2016)
Drimane Sesquiterpenoids Noncompetitively Inhibit Human α4β2 Nicotinic Acetylcholine Receptors with Higher Potency Compared to Human α3β4 and α7 Subtypes
(American Chemical Society, 2018-04)
The drimane sesquiterpenoids drimenin, cinnamolide, dendocarbin A, and polygodial were purified from the Canelo tree (Drimys winteri) and chemically characterized by spectroscopic methods. The pharmacological activity of ...
Catecholamines inhibit α/β interferon production induced by lipopolysaccharide
(1996)
In vitro incubation of Listeria monocytogenes immune spleen cells in the presence of the catecholamines epinephrine or norepinephrine inhibited the α/β-interferon (IFN α/β) synthesis induced by the mitogen lipopolysaccharide, ...
Inhibición de la α-amilasa por medio de extractos de plantas medicinales como tratamiento complementario/alternativo de la diabetes y la caries
(Sociedad odontológica de La Plata, 2018)
Los inhibidores selectivos de la α-amilasa salival y pancreática humana, son un medio eficaz para controlar los niveles de azúcar en la saliva y la sangre, durante el control de la caries y la diabetes. En la presente ...
Molecular determinants for competitive inhibition of α4β2 nicotinic acetylcholine receptors
(American Society for Pharmacology and Experimental Therapy, 2010)
The Erythrina alkaloids erysodine and dihydro-β-erythroidine (DHβE) are potent and selective competitive inhibitors of α4β2 nicotinic acetylcholine receptors (nAChRs), but little is known about the molecular determinants ...