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TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation
(Elsevier, 2018)
Objective
Diabetic retinopathy (DR) is induced by an accumulation of reactive metabolites such as ROS, RNS, and RCS species, which were reported to modulate the activity of cation channels of the TRPC family. In this ...
TRPC6 binds to and activates calpain, independent of its channel activity, and regulates podocyte cytoskeleton, cell adhesion, and motility
(American Society of Nephrology, 2019)
Background: Mutations in transient receptor potential channel 6 (TRPC6) are associated with an inherited form of focal segmental glomerulosclerosis (FSGS). Despite widespread expression, patients with TRPC6 mutations do ...
Lipid-independent control of endothelial and neuronal TRPC3 channels by light
(Royal Society of Chemistry, 2019)
Abstract: Lipid-gated TRPC channels are highly expressed in cardiovascular and neuronal tissues. Exerting precise pharmacological control over their activity in native cells is expected to serve as a basis for the development ...
TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca2+ concentration in mouse cardiomyocytes
(Springer Tokyo, 2017-01)
When a cardiac muscle is held in a stretched position, its [Ca2+] transient increases slowly over several minutes in a process known as stress-induced slow increase in intracellular Ca2+ concentration ([Ca2+]i) (SSC). ...
M1 Macrophage Polarization Is Dependent on TRPC1-Mediated Calcium Entry
(Elsevier Inc., 2018-10)
Macrophage plasticity is essential for innate immunity, but in-depth signaling mechanism(s) regulating their functional phenotypes are ill-defined. Here we report that interferon (IFN) g priming of naive macrophages induces ...
M1 macrophage polarization is dependent on TRPC1-mediated calcium entry
(Elsevier (Cell Press), 2018)
Abstract: Macrophage plasticity is essential for innate immunity, but in-depth signaling mechanism(s) regulating their functional phenotypes are ill-defined. Here we report that interferon (IFN) γ priming of naive macrophages ...
Effects of tetrahydrohyperforin in mouse hippocampal slices: neuroprotection, long-term potentiation and trpc channels
(BENTHAM SCIENCE PUBLISHERS, 2014)