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Lipid peroxidation modifies the picture of membranes from the “Fluid Mosaic Model” to the “Lipid Whisker Model”
(Elsevier Masson, 2012-01)
The “Fluid Mosaic Model”, described by Singer and Nicolson, explain both how a cell membrane preserves a critical barrier function while it concomitantly facilitates rapid lateral diffusion of proteins and lipids within ...
The late endocytic Rab39a GTPase regulates the interaction between multivesicular bodies and chlamydial inclusions.
(Company of Biologists, 2015-08)
Given their obligate intracellular lifestyle, Chlamydia trachomatis ensure their access to multiple host sources of essential lipids by interfering vesicular transport. These bacteria hijack Rab6-, Rab11- and Rab14-controlled ...
Ceramide-1-phosphate: a new mediator of survival and development in retina photoreceptors
(Association For Research In Vision And Ophthalmology, 2011-08)
Purpose. Simple sphingolipids control crucial cellular processes in several cell types. We demonstrated that sphingolipids such as ceramide, sphingosine and sphingosine-1-phosphate are key mediators in the regulation of ...
Sphingosine-1 phosphate: A new modulator of immune plasticity in the tumor microenvironment
(Frontiers Media S.A., 2016-10-17)
In the last 15 years, increasing evidences demonstrate a strong link between sphingosine-1-phosphate (S1P) and both normal physiology and progression of different diseases, including cancer and inflammation. Indeed, numerous ...
Optimized protocols to analyze sphingosine 1-phosphate signal transduction pathways during acrosomal exocytosis in human sperm
(Humana Press, 2012)
Regulated secretion is a central issue for the specific function of many cells; for instance, mammalian sperm acrosomal exocytosis is essential for egg fertilization. Sphingosine 1-phosphate is a bioactive sphingolipid ...
Psychosine remodels model lipid membranes at neutral pH
(Elsevier Science, 2018-12)
β-Galactosylsphingosine or psychosine (PSY) is a single chain sphingolipid with a cationic group, which is degraded in the lysosome lumen by β-galactosylceramidase during sphingolipid biosynthesis. A deficiency of this ...
Abnormal Glycosphingolipid Mannosylation Triggers Salicylic Acid-Mediated Responses in Arabidopsis
(American Society of Plant Biologists, 2013-05)
The Arabidopsis thaliana protein GOLGI-LOCALIZED NUCLEOTIDE SUGAR TRANSPORTER (GONST1) has been previously identified as a GDP-D-mannose transporter. It has been hypothesized that GONST1 provides precursors for the synthesis ...
Identification of modifier genes/networks of lysosomal biology
(Universidad del Desarrollo. Facultad de Medicina, 2023)
Lysosomal storage diseases (LSDs) are a heterogeneous group of ~70 rare inherited metabolic diseases caused by loss-of-function variants in genes encoding for lysosomal enzymes, their activators, or transport proteins. ...
UV-MALDI mass spectrometry analysis of NBD-glycosphingolipids without an external matrix
(American Chemical Society, 2021)
UV-MALDI mass spectrometry analysis of NBD-glycosphingolipids without an external matrix
(American Chemical Society, 2021)