Artículos de revistas
Lipid peroxidation modifies the picture of membranes from the “Fluid Mosaic Model” to the “Lipid Whisker Model”
Catala, Angel; Lipid peroxidation modifies the picture of membranes from the “Fluid Mosaic Model” to the “Lipid Whisker Model”; Elsevier Masson; Biochimie; 94; 1; 1-2012; 101-109
The “Fluid Mosaic Model”, described by Singer and Nicolson, explain both how a cell membrane preserves a critical barrier function while it concomitantly facilitates rapid lateral diffusion of proteins and lipids within the planar membrane surface. However, the lipid components of biological plasma membranes are not regularly distributed. They are thought to contain “rafts” e nano-domains enriched in sphingolipids and cholesterol that are distinct from surrounding membranes of unsaturated phospholipids. Cholesterol and fatty acids adjust the transport and diffusion of molecular oxygen in membranes. The presence of cholesterol and saturated phospholipids decreases oxygen permeability across the membrane. Alpha-tocopherol, the main antioxidant in biological membranes, partition into domains that are enriched in polyunsaturated phospholipids increasing the concentration of the vitamin in the place where it is most required. On the basis of these observations, it is possible to assume that non-raft domains enriched in phospholipids containing PUFAs and vitamin E will be more accessible by molecular oxygen than lipid raft domains enriched in sphingolipids and cholesterol. This situation will render some nano-domains more sensitive to lipid peroxidation than others. Phospholipid oxidation products are very likely to alter the properties of biological membranes, because their polarity and shape may differ considerably from the structures of their parent molecules. Addition of a polar oxygen atom to several peroxidized fatty acids reorients the acyl chain whereby it no longer remains buried within the membrane interior, but rather projects into the aqueous environment “Lipid Whisker Model”. This exceptional conformational change facilitates direct physical access of the oxidized fatty acid moiety to cell surface scavenger receptors.
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Lipid-based nanoformulations in the treatment of neurological disorders Pottoo F.H.; Sharma S.; Javed M.N.; Barkat M.A.; Harshita; Alam M.S.; Naim M.J.; Alam O.; Ansari M.A.; Barreto G.E.; Ashraf G.M. (Taylor and Francis Ltd, 2020)
Important aspects in the knowledge of protein–lipid interactions from 1900 up to 2017 Catala, Angel (Nova Science Publishers, 2018)In the last five decades, the significance of protein-lipid interactions in biological systems began to be widely explored; the most important hand marks in the knowledge of protein-lipid interactions from 1969 up to now ...
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