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Mostrando ítems 81-90 de 115
New Insights into the Roles of Megalin/LRP2 and the Regulation of its Functional Expression
(Sociedad de Biología de Chile, 2011)
Caracterização do sistema renina angiotensina no rim e coração do camundongo transgênico que expressa tonina de rato
(Universidade Federal de São Paulo (UNIFESP), 2010-05-26)
Angiotensin II (Ang II), one of the most relevant angiotensinergic peptides, has an important role in the renal and cardiac physiology. There are many enzymes that generate Ang II. One of them is tonin, that is able to ...
Nanopartículas plasmónicas para la detección de agregados del péptido β-amiloide mediante fluorescencia aumentada por superficie
(Universidad de Chile, 2020)
Una de las hipótesis más aceptada para la etiología de la enfermedad de Alzheimer (EA) es
la “hipótesis de la cascada amiloide”. Esta hipótesis se centra en la acumulación de
agregados tóxicos del péptido β-amiloide (Aβ), ...
Sinalização por notch e galectina-3 na indução do programa de neurogênese latente de astrócitos reativos
(Universidade Federal de São Paulo, 2021-07-20)
A reativação astrocitária é uma das principais respostas celulares após lesão do sistema nervoso central. Astrócitos reativos auxiliam o fechamento e reparo do tecido danificado ao adquirirem um programa celular regenerativo, ...
Caracterização de modelos de experimentação baseados na Doença de Alzheimer em zebrafish
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2015)
New animal models for neurodegenerative diseases study are necessary for the knowledge of molecular mechanisms and behavioral patterns involved on the progression of dementias as Alzheimer’s Disease (AD) as well as for new ...
Altered APP Processing in PDAPP (Val717 → Phe) Transgenic Mice Yields Extended-Length Aβ Peptides.
(American Chemical Society, 2005-10)
Central to the pathology of Alzheimer's disease (AD) is the profuse accumulation of amyloid-beta (Abeta) peptides in the brain of affected individuals, and several amyloid precursor protein (APP) transgenic (Tg) mice models ...
Presenilin-1 280Glu-->Ala mutation alters C-terminal APP processing yielding longer abeta peptides: implications for Alzheimer's disease
(Feinstein Institute for Medical Research, 2008-03)
Presenilin (PS) mutations enhance the production of the Abeta42 peptide that is derived from the amyloid precursor protein (APP). The pathway(s) by which the Abeta42 species is preferentially produced has not been elucidated, ...
Alzheimer's Disease Biomarker Profile in Cerebrospinal Fluid of Individuals With Immune-Mediated Encephalitis
(American Geriatrics Society, 2016-06)
All of these individuals had rapid onset of dementia,with cognitive fluctuation, neuropsychiatric symptoms, andseizures. The individuals underwent brain magnetic resonance imaging (MRI), CSF analysis, and tumor screening.An ...
Alzheimer’s Disease as a Membrane Disorder: Spatial Cross-Talk Among Beta-Amyloid Peptides, Nicotinic Acetylcholine Receptors and Lipid Rafts
(Frontiers Media S.A., 2019-07-18)
Biological membranes show lateral and transverse asymmetric lipid distribution. Cholesterol (Chol) localizes in both hemilayers, but in the external one it is mostly condensed in lipid-ordered microdomains (raft domains), ...