Articulo
Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes
J Biol Chem
Registro en:
13980001
13980001
Autor
Lee, J.
Retamal, C.
Cuitiño, L.
Caruano-Yzermans, A.
Shin, J. E.
van Kerkhof, P.
Marzolo, M. P.
Bu, G.
Institución
Resumen
Accumulation of extracellular amyloid beta peptide (Abeta), generated from amyloid precursor protein (APP) processing by beta- and gamma-secretases, is toxic to neurons and is central to the pathogenesis of Alzheimer disease. Production of Abeta from APP FONDAP FONDAP