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Tyrosyl-DNA-phosphodiesterase I (TDP1) participates in the removal and repair of stabilized-Top2α cleavage complexes in human cells
(Elsevier Science, 2015-11)
Tyrosyl-DNA-phosphodiesterase 1 (TDP1) is a DNA repair enzyme that removes irreversible protein-linked 3′ DNA complexes, 3′ phosphoglycolates, alkylation damage-induced DNA breaks, and 3′ deoxyribose nucleosides. In addition ...
Rv2577 of mycobacterium tuberculosis Is a virulence factor with dual phosphatase and phosphodiesterase functions
(Frontiers Media, 2020)
Tuberculosis, a lung disease caused by Mycobacterium tuberculosis (Mtb), is one of the ten leading causes of death worldwide affecting mainly developing countries. Mtb can persist and survive inside infected cells through ...
Sildenafil for pulmonary hypertension treatment after cardiac surgery
(2005-03-01)
Objective: To report on the use of sildenafil for pulmonary hypertension treatment of a newborn patient after cardiac surgery. Description: A female, full term newborn infant with diagnosis of double outlet right ventricle, ...
Sildenafil for pulmonary hypertension treatment after cardiac surgery
(2005-03-01)
Objective: To report on the use of sildenafil for pulmonary hypertension treatment of a newborn patient after cardiac surgery. Description: A female, full term newborn infant with diagnosis of double outlet right ventricle, ...
Evidence of a Ca(2+)-(center dot)NO-cGMP signaling pathway controlling zoospore biogenesis in the aquatic fungus Blastocladiella emersonii
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2009)
The sporulation stage of the aquatic fungus Blastocladiella emersonii culminates with the formation and release to the medium of a number of zoospores, which are motile cells responsible for the dispersal of the fungus. ...
Intracellular cyclic AMP levels modulate differential adaptive responses on epimastigotes and cell culture trypomastigotes of Trypanosoma cruzi
(Elsevier Science, 2020-02)
Among the many environmental challenges the parasiteTrypanosoma cruzihas to overcome to complete its lifecycle through different hosts, oxidative stress plays a central role. Different stages of this parasite encounterdistinct ...
Altered reactivity of gastric fundus smooth muscle in the mouse with targeted disruption of the kinin B(1) receptor gene
(ELSEVIER SCIENCE INC, 2009)
Relaxing action of sodium nitroprusside (SNP) was significantly reduced in the stomach fundus of mice lacking the kinin B(1) receptor (B(1)(-/-)). Increased basal cGMP accumulation was correlated with attenuated SNP induced ...
Biochemical and biological characterization of Ecuadorian pitviper venoms (genera Bothriechis, Bothriopsis, Bothrops and Lachesis)
(1996-06)
The lethality and enzymatic activities of venoms from six Ecuadorian pitvipers (Bothriechis schlegelii, Bothriopsis punctata, Bothriopsis taeniata, Bothrops asper, Bothrops atrox and Lachesis muta) are similar to those of ...
Biochemical and biological characterization of Ecuadorian pitviper venoms (genera Bothriechis, Bothriopsis, Bothrops and Lachesis)
(1996-06)
The lethality and enzymatic activities of venoms from six Ecuadorian pitvipers (Bothriechis schlegelii, Bothriopsis punctata, Bothriopsis taeniata, Bothrops asper, Bothrops atrox and Lachesis muta) are similar to those of ...