Artículos de revistas
Sildenafil for pulmonary hypertension treatment after cardiac surgery
Fecha
2005-03-01Registro en:
Jornal de Pediatria, v. 81, n. 2, p. 175-178, 2005.
0021-7557
10.2223/1325
2-s2.0-28244457913
2-s2.0-28244457913.pdf
2559637400719543
0246391303241376
9919910234219937
1197755531108177
0000-0002-0648-876X
Autor
Universidade Estadual Paulista (Unesp)
Institución
Resumen
Objective: To report on the use of sildenafil for pulmonary hypertension treatment of a newborn patient after cardiac surgery. Description: A female, full term newborn infant with diagnosis of double outlet right ventricle, pulmonary hypoplasia and subaortic ventricular septal defect, was submitted to Blalock surgery in the first week of life. In postoperative the newborn had pulmonary hypertension and persistent hypoxia, without response to nitric oxide, but with improved oxygenation after continuous intravenous infusion of prostaglandin E1. After several failed attempts to discontinue prostaglandin E1, oral sildenafil was used. There was a decrease in pulmonary vascular resistance with consequent oxygenation improvement and 48 hours later it was possible to discontinue prostaglandin E1 infusion. Comments: Sildenafil can be an alternative therapy for pulmonary hypertension, especially when there is no response to conventional therapy. Copyright © 2005 by Sociedade Brasileira de Pediatria.