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TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice
(Wiley, 2017)
Abstract: Canonical transient receptor potential (TRPC) channels constitute a family of cation channels that exhibit a regional and cell-specific expression pattern throughout the brain. It has been reported previously ...
TRPC1 participates in the HSV-1 infection process by facilitating viral entry
(Science Advances is the American Association for the Advancement of Science, 2021-03)
Mammalian transient receptor potential (TRP) channels are major components of Ca2+ signaling pathways and control a diversity of physiological functions. Here, we report a specific role for TRPC1 in the entry of herpes ...
TRPC6 is the endothelial calcium channel that regulates leukocyte transendothelial migration during the inflammatory response
(Rockefeller University Press, 2015-09)
Leukocyte transendothelial migration (TEM) is a tightly regulated, multistep process that is critical to the inflammatory response. A transient increase in endothelial cytosolic free calcium ion concentration (↑[Ca2+]i) ...
TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN
(Federation of American Societies for Experimental Biology, 2019-09)
Vascular smooth muscle cells (VSMCs) play critical roles in the stability and tonic regulation of vascular homeostasis. VSMCs can switch back and forth between highly proliferative synthetic and fully differentiated ...
Major contribution of the 3/6/7 class of TRPC channels to myocardial ischemia/reperfusion and cellular hypoxia/reoxygenation injuries
(National Academy of Sciences, 2017-05)
The injury phase after myocardial infarcts occurs during reperfusion and is a consequence of calcium release from internal stores combined with calcium entry, leading to cell death by apoptopic and necrotic processes. The ...
TRPC3/6/7 Knockdown Protects the Brain from Cerebral Ischemia Injury via Astrocyte Apoptosis Inhibition and Effects on NF-кB Translocation
(Springer, 2016-11)
Ischemia contributes significantly to morbidity and mortality associated with many common neurological diseases. Calcium overload is an important mechanism of cerebral ischemia and reperfusion (I/R) injury. Despite decades ...
Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy
(National Academy of Sciences, 2014-01-28)
Chronic neurohormonal and mechanical stresses are central fea-tures of heart disease. Increasing evidence supports a role forthe transient receptor potential canonical channels TRPC3 andTRPC6 in this pathophysiology. Channel ...
La sobre-expresión del canal trpc6 y mutantes asociadas a glomeruloesclerosis focal y segmentaria (gefs) producen una enfermedad proteinúrica renal cn pérdida de podocitos
(2010)
La glomeruloesclerosis focal y segmentaría (GEFS) es una enfermedad renal que
puede ser idiopática, producida por mutaciones genéticas o secundaria a otras condiciones
o patologías. Se caracteriza morfológicamente por la ...
Blockade of Stim-activated TRPC-ORAI Channels Prevents Vascular Remodeling and Pulmonary Hypertension Induced by Chronic Intermittent Hypoxia
(NLM (Medline), 2022)
© FASEB.Obstructive sleep apnea (OSA), a sleep breathing disorder featured by chronic intermittent hypoxia (CIH), is associate with mild pulmonary hypertension (PH). Rats exposed to CIH developed pulmonary vascular remodeling ...