Artículos de revistas
TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice
Fecha
2017Registro en:
0013-9580
1528-1167 (online)
10.1111/epi.13648
28012173
Autor
Phelan, Kevin D.
Shwe, U Thaung
Cozart, Michael A.
Wu, Hong
Mock, Matthew M.
Abramowitz, Joel
Birnbaumer, Lutz
Zheng, Fang
Institución
Resumen
Abstract: Canonical transient receptor potential (TRPC) channels constitute a family of cation channels that exhibit a regional and cell-specific expression pattern throughout the brain. It has been reported previously that TRPC3 channels are effectors of the brain-derived neurotrophic factor (BDNF)/trkB signaling pathway. Given the long postulated role of BDNF in epileptogenesis, TRPC3 channels may be a critical component in the underlying pathophysiology of seizure and epilepsy. In this study, we investigated the precise role of TRPC3 channels in pilocarpine-induced status epilepticus (SE).