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Mostrando ítems 71-80 de 1939
Extracellular calcium modulates proliferation of factor dependent hemopoietic cells
(1993)
Blockade of the calcium channel inhibited, in a dose‐dependent manner, the proliferation of the IL‐3 dependent FDCP‐1 cell line and normal murine bone marrow cells. Similar results were obtained by lowering the amount of ...
Role of the S4 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 1998-12-04)
We investigated the role of individual charged residues of the S4 region of a MaxiK channel (hSlo) in channel gating, We measured macroscopic currents induced by wild type (WT) and point mutants of hSlo in inside-out ...
Cocaine Enhances Gamma-Aminobutyric Acid Release From Reticular Thalamic Nucleus: Role of T-Type Calcium Channels
(Academic Press, 2017)
Thalamic reticular nucleus (TRN) neurons are extensivelymodulated by cocaines inhibition of catecholaminereuptake at both the somatic and synaptic levels. Systemic cocaine binge administration in miceenhanced gamma-aminobutyric ...
Conotoxins as tools to understand the physiological function of voltage-gated calcium (ca-v) channels
(2017)
Voltage-gated calcium (Ca-V) channels are widely expressed and are essential for the completion of multiple physiological processes. Close regulation of their activity by specific inhibitors and agonists become fundamental ...
External copper inhibits the activity of the large-conductance calcium- and voltage-sensitive potassium channel from skeletal muscle
(2003)
We have characterized the effect of external
copper on the gating properties of the large-conductance calcium- and voltage-sensitive potassium channel from skeletal muscle, incorporated into artificial
bilayers. The ...
L-type calcium channel β subunit modulates angiotensin II responses in cardiomyocytes
(Taylor and Francis Inc., 2011)
Angiotensin II regulation of L-type calcium currents in cardiac muscle is controversial and the underlying signaling events are not completely understood. Moreover, the possible role of auxiliary subunit composition of the ...
Single Ca2+-activated Cl- channel currents recorded from toad olfactory cilia
(Biomed Central, 2016)
Background: Odor transduction, occurring in the chemosensory cilia of vertebrate olfactory sensory neurons, is triggered by guanosine triphosphate-coupled odor receptors and mediated by a cyclic adenosine monophosphate ...
L-Type Calcium Channels Modulation by Estradiol
(2017-09-01)
Voltage-gated calcium channels are key regulators of brain function, and their dysfunction has been associated with multiple conditions and neurodegenerative diseases because they couple membrane depolarization to the ...
Melanocortin 4 receptor activation inhibits presynaptic N-type calcium channels in amygdaloid complex neurons
(Wiley Blackwell Publishing, Inc, 2014-06)
The melanocortin 4 receptor (MC4R) is a G protein-coupled receptor involved in food intake and energy expenditure regulation. MC4R activation modifies neuronal activity but the molecular mechanisms by which this regulation ...