Extracellular calcium modulates proliferation of factor dependent hemopoietic cells

Abstract

Blockade of the calcium channel inhibited, in a dose‐dependent manner, the proliferation of the IL‐3 dependent FDCP‐1 cell line and normal murine bone marrow cells. Similar results were obtained by lowering the amount of extracellular calcium using specific chelators or a calcium‐free medium. These results suggest that factor‐dependent cell proliferation is highly sensitive to fluctuations in the concentration of extracellular calcium. Copyright © 1993 John Wiley & Sons Ltd.