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Down regulation of the proliferation and apoptotic pathways in the embryonic brain of diabetic rats
(Springer/Plenum Publishers, 2012-08)
Compelling evidence shows that the offspring subjected to uncontrolled hyperlycemia during gestation display behavioral, neurochemical, and cellular abnormalities during adulthood. However, the molecular mechanisms underlying ...
Changes of myoid and endothelial cells in the peritubular wall during contraction of the seminiferous tubule
(Springer, 2016-08)
The wall of the seminiferous tubule in rodents consists of an inner layer of myoid cells covered by an outer layer of endothelial cells. Myoid cells are a type of smooth muscle cell containing α-actin filaments arranged ...
VERO cells harbor a poly-ADP-ribose belt partnering their epithelial adhesion belt
(PeerJ, 2014-10-14)
Poly-ADP-ribose (PAR) is a polymer of up to 400 ADP-ribose units synthesized by poly-ADP-ribose-polymerases (PARPs) and degraded by poly-ADP-ribose-glycohydrolase (PARG). Nuclear PAR modulates chromatin compaction, affecting ...
Determination of cytokeratins 1, 13 and 14 in oral lichen planus
(Medicina Oral S L, 2014-07)
Cytokeratins (CK) are molecules of the cytoskeleton that contribute to the cellular differenciation. We studied the expression of CK1, CK13 and CK14 in thirty-three patients with OLP. The biopsied lesions were located in ...
A pore-forming toxin enables Serratia a nonlytic egress from host cells
(Wiley Blackwell Publishing, Inc, 2016-08)
Several pathogens co-opt host intracellular compartments to survive and replicate, and they thereafter disperse progeny to prosper in a new niche. Little is known about strategies displayed by Serratia marcescens to defeat ...
A novel stage-specific glycosomal nucleoside diphosphate kinase from Trypanosoma cruzi
(Czech Academy of Sciences. Institute of Parasitology, 2017-02)
Nucleoside diphosphate kinases (NDPK) are key enzymes involved in the intracellular nucleotide maintenance in all living organisms, especially in trypanosomatids which are unable to synthesise purines de novo. Four putative ...
Anomalous dynamics of melanosomes driven by myosin-V in Xenopus laevis melanophores
(Cell Press, 2009-09)
The organization of the cytoplasm is regulated by molecular motors, which transport organelles and other cargoes along cytoskeleton tracks. In this work, we use single particle tracking to study the in vivo regulation of ...
Changes of myoid and endothelial cells in the peritubular wall during contraction of the seminiferous tubule
(Springer, 2016)
The wall of the seminiferous tubule in rodents consists of an inner layer of myoid cells covered by an outer layer of endothelial cells. Myoid cells are a type of smooth muscle cell containing α-actin filaments arranged ...
Proteomic study revealed cellular assembly and lipid metabolism dysregulation in sepsis secondary to community-acquired pneumonia
(Nature Publishing Group, 2017)
Sepsis is a life-threatening disorder characterized by organ dysfunction and a major cause of mortality worldwide. The major challenge in studying sepsis is its diversity in such factors as age, source of infection and ...
Unique behavior of Trypanosoma cruzi mevalonate kinase: A conserved glycosomal enzyme involved in host cell invasion and signaling
(Nature Publishing Group, 2016)
Mevalonate kinase (MVK) is an essential enzyme acting in early steps of sterol isoprenoids biosynthesis, such as cholesterol in humans or ergosterol in trypanosomatids. MVK is conserved from bacteria to mammals, and localizes ...