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Single and combined effect of retinoic acid and rapamycin modulate the generation, activity and homing potential of induced human regulatory T cells
(Public Library Science, 2017)
Adoptive transfer of CD4+CD25+FOXP3+ regulatory T cells (Treg cells) has been successfully
utilized to treat graft versus host disease and represents a promising strategy for the
treatment of autoimmune diseases and ...
Estudo de células T regulatórias em camundongos deficientes em WASP
(2014)
A Síndrome de Wiskott-Aldrich (WAS) é uma imunodeficiência associada a infecções recorrentes, câncer e autoimunidade. Ela é causada por mutações no gene que codifica a molécula WASP (\201CWiskott-Aldrich syndrome protein\201D), ...
Vitamin D modulates the transcription factors of T cell subsets to anti-inflammatory and regulatory profiles in preeclampsia
(2021-01-01)
Vitamin D (VD) is a multifunctional prohormone and low VD status in pregnancy may contribute to the risk of adverse perinatal outcomes, such as preeclampsia (PE). This molecule may modulate the polarization of T cell subsets ...
Mechanisms involved in the expansion of Tregs during pregnancy: Role of IL-2/STAT5 signalling
(Elsevier Ireland, 2011-03)
Several studies have reported that the fine-tuning of regulatory T cells (Tregs) is required for a successful pregnancy and for the control of autoimmune diseases. Here, we review the mechanisms that control the expansion ...
Análise do padrão de resposta Th17 e de células T regulatórias em pacientes com a forma digestiva da doença de Chagas crônica
(Universidade Estadual Paulista (UNESP), 2016)
Anti-CD25 Treatment Depletes Treg Cells and Decreases Disease Severity in Susceptible and Resistant Mice Infected with Paracoccidioides brasiliensis
(Derya UnutmazSAN FRANCISCO, 2012-11-30)
Regulatory T (Treg) cells are fundamental in the control of immunity and excessive tissue pathology. In paracoccidioidomycosis, an endemic mycosis of Latin America, the immunoregulatory mechanisms that control the progressive ...
Trichostatin A Promotes the Generation and Suppressive Functions of Regulatory T Cells
(Hindawi, 2013)
Regulatory T cells are a specific subset of lymphocytes that suppress immune responses and play a crucial role in the maintenance
of self-tolerance. They can be generated in the thymus as well as in the periphery through ...
Trichostatin a promotes the generation and suppressive functions of regulatory T cells
(Hindawi Limited, 2013-05)
Regulatory T cells are a specific subset of lymphocytes that suppress immune responses and play a crucial role in the maintenance of self-tolerance. They can be generated in the thymus as well as in the periphery through ...