info:eu-repo/semantics/article
Mechanisms involved in the expansion of Tregs during pregnancy: Role of IL-2/STAT5 signalling
Fecha
2011-03Registro en:
Arruvito, Maria Lourdes; Fainboim, Leonardo; Mechanisms involved in the expansion of Tregs during pregnancy: Role of IL-2/STAT5 signalling; Elsevier Ireland; Journal of Reproductive Immunology; 88; 2; 3-2011; 93-98
0165-0378
CONICET Digital
CONICET
Autor
Arruvito, Maria Lourdes
Fainboim, Leonardo
Resumen
Several studies have reported that the fine-tuning of regulatory T cells (Tregs) is required for a successful pregnancy and for the control of autoimmune diseases. Here, we review the mechanisms that control the expansion of Tregs, based on insights obtained from the study of women suffering unsuccessful pregnancies and on recent data from patients with autoimmune diseases or with chronic viral infections such as HCV. In particular, we review the role of endocrine factors and IL-2/STAT5 signalling in the impaired expansion of Tregs.