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Dual effect of serotonin on the dendritic growth of cultured hippocampal neurons: Involvement of 5-HT1A and 5-HT7 receptors
(Academic Press Inc., 2017)
© 2017 Elsevier Inc. Serotonin acts through its receptors (5-HTRs) to shape brain networks during development and modulates essential functions in mature brain. The 5-HT1AR is mainly located at soma of hippocampal neurons ...
4-Bromo-2,5-dimethoxyphenethylamine (2C-B) and structurally related phenylethylamines are potent 5-HT2A receptor antagonists in Xenopus laevis oocytes
(Nature Publishing Group, 2004-02-04)
1 We recently described that several 2-(2,5-dimethoxy-4-substituted phenyl)ethylamines (PEAs),
including 4-I¼2C-I, 4-Br¼2C-B, and 4-CH3¼2C-D analogs, are partial agonists at 5-HT2C
receptors, and show low or even negligible ...
Two-dimensional QSAR studies on arylpiperazines as high-affinity 5-HT(1A) receptor ligands
(BENTHAM SCIENCE PUBL LTD, 2008)
5-HT(1A) receptor plays an important role in the delayed onset of antidepressant action of a class of selective serotonin reuptake inhibitors. Moreover, 5-HT(1A) receptor levels have been shown to be altered in patients ...
Interplay between 5-HT2C and 5-HT1A receptors in the dorsal periaqueductal gray in the modulation of fear-induced antinociception in mice
(2018-09-15)
The confinement of rodents to the open arm of the elevated-plus maze provokes antinociception (OAA). As a type of defensive reaction, the OAA has been investigated through systemic and intramesencephalic (e.g., dorsal ...
A chemometric study of the 5-HT1A receptor affinities presented by arylpiperazine compounds
(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2008)
Arylpiperazine compounds are promising 5-HT1A receptor ligands that can contribute for accelerating the onset of therapeutic effect of selective serotonin reuptake inhibitors. In the present work, the chemometric methods ...
Agonistas de receptores serotoninérgicos activan cascadas transduccionales involucradas en la regulación del citoesqueleto y producen cambios en la morfología de neuronas hipocampales en cultivo
(Universidad de Chile, 2013)
La Serotonina (5-HT) es un neurotransmisor detectado tempranamente durante el desarrollo del
sistema nervioso central y recientemente se ha descrito su papel sobre los procesos de migración
y morfología neuronal. Mediante ...