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Nerve growth factor induces cell cycle arrest of astrocytes
(John Wiley & Sons Inc, 2012-06)
Neurotrophins can influence multiple cellular functions depending on the cellular context and the specific receptors they interact with. These neurotrophic factors have been extensively studied for their ability to support ...
Loss of TrkB signaling due to status epilepticus induces a proBDNF-dependent cell death
(Frontiers Research Foundation, 2019-01-08)
Neurotrophins (NTs) are secretory proteins that bind to target receptors and influence many cellular functions, such as cell survival and cell death in neurons. The mammalian NT brain-derived neurotrophic factor (matBDNF) ...
c-Jun N-terminal kinase (JNK)-dependent internalization and Rab5-dependent endocytic sorting mediate long-distance retrograde neuronal death induced by axonal BDNF-p75 signaling
(NATURE PUBLISHING GROUP, 2019)
During the development of the sympathetic nervous system, signals from tropomyosin-related kinase receptors (Trks) and p75 neurotrophin receptors (p75) compete to regulate survival and connectivity. During this process, ...
c-Jun N-terminal kinase (JNK)- dependent internalization and Rab5-dependent endocytic sorting mediate long-distance retrograde neuronal death induced by axonal BDNF-p75 signaling
(2019)
During the development of the sympathetic nervous system, signals from tropomyosin-related kinase receptors (Trks) and p75 neurotrophin receptors (p75) compete to regulate survival and connectivity. During this process, ...
Tratamento crônico com tamoxifeno de maneira dose-dependente afeta a memória e os fenótipos do tipo ansioso e depressivo em ratas Wistar intactas
(Universidade Federal de Santa MariaBrasilBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica ToxicológicaCentro de Ciências Naturais e Exatas, 2022-07-28)
Tamoxifen, a selective estrogen receptor modulator, the gold standard for adjuvant therapy of breast cancer, has dichotomous effects on memory, anxious- and depressive-like phenotypes described in the literature. Studies ...
El péptido A[beta] en concentraciones nanomolares es capaz de modular la actividad del R-NMDA en la DPS por interacción con el receptor p75NTR
(Universidad de Chile, 2009)
La enfermedad de Alzheimer (EA) es una patología neurodegenerativa progresiva
caracterizada principalmente por agregados proteicos intracelulares (ovillos
neurofibrilares) y extracelulares (placas seniles o amiloides). ...
Chronic stress decreases the expression of sympathetic markers in the pineal gland and increases plasma melatonin concentration in rats
(WILEY, 2006)
Chronic stress affects brain areas involved in learning and emotional responses. Although most studies have concentrated on the effect of stress on limbic-related brain structures, in this study we investigated whether ...