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The role of leukotriene B4 in early stages of experimental paracoccidioidomycosis induced in phenotypically selected mouse strains
(2013-08-01)
Paracoccidioidomycosis is a human systemic mycosis caused by the fungus Paracoccidioides brasiliensis. The mechanisms involved in innate immune response to this fungus are not fully elucidated. Leukotrienes are known to ...
The role of leukotriene B4 in early stages of experimental paracoccidioidomycosis induced in phenotypically selected mouse strains
(2013-08-01)
Paracoccidioidomycosis is a human systemic mycosis caused by the fungus Paracoccidioides brasiliensis. The mechanisms involved in innate immune response to this fungus are not fully elucidated. Leukotrienes are known to ...
Anxiogenic-like effect induced by TRPV1 receptor activation within the dorsal periaqueductal gray matter in mice
(2013-08-01)
Pharmacological manipulation of TRPV1 (Transient Receptor Potential Vanilloid type-1) receptors has been emerging as a novel target in the investigation of anxiety states. Here, we attempt to show the role played by the ...
Papel das proteínas Yops de Yersinia pseudotuberculosis na ativação dos linfócitos B
(2003-12-01)
The virulence plasmid common to pathogenic Yersinia species encodes a number of secreted proteins denoted Yops (Yersinia outer proteins). The Yops effectors have been related to a set of biological properties, including ...
Papel das proteínas Yops de Yersinia pseudotuberculosis na ativação dos linfócitos B
(2003-12-01)
The virulence plasmid common to pathogenic Yersinia species encodes a number of secreted proteins denoted Yops (Yersinia outer proteins). The Yops effectors have been related to a set of biological properties, including ...
Anxiogenic-like effect induced by TRPV1 receptor activation within the dorsal periaqueductal gray matter in mice
(2013-08-01)
Pharmacological manipulation of TRPV1 (Transient Receptor Potential Vanilloid type-1) receptors has been emerging as a novel target in the investigation of anxiety states. Here, we attempt to show the role played by the ...
Anti-VP6 VHH: An Experimental Treatment for Rotavirus A-Associated Disease
(Public Library of Science, 2016-09)
Species A Rotaviruses (RVA) remain a leading cause of mortality in children under 5 years of age. Current treatment options are limited. We assessed the efficacy of two VP6-specific llama-derived heavy chain antibody ...
Benznidazole/Poloxamer 407 Solid Dispersion as a New Strategy to Improve the Treatment of Experimental Trypanosoma cruzi Infection
(American Society of Parasitologists, 2020-05-04)
Benznidazole and nifurtimox are the only drugs specifically approved for the treatment of Chagas disease. Both compounds are given orally in tablets, but occasionally are ineffective and cause adverse effects. Benznidazole, ...