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Mostrando ítems 61-70 de 96
Synthesis, biological evaluation and molecular modeling studies of substitutedN-benzyl-2-phenylethanamines as cholinesterase inhibitors
(Royal Society of Chemistry, 2020-06)
In this work, we report the synthesis of a series of derivatives of N-benzyl-2-phenylethanamine which is the framework of norbelladine, the natural common precursor of the Amaryllidaceae alkaloids. These compounds were ...
Machine learning models to select potential inhibitors of acetylcholinesterase activity from SistematX: a natural products database
(2021)
Alzheimer's disease is the most common form of dementia, representing 60-70% of dementia cases. The enzyme acetylcholinesterase (AChE) cleaves the ester bonds in acetylcholine and plays an important role in the termination ...
Estudos bioquímicos e cinéticos de acetilcolinesterases de formigas cortadeiras (Atta sexdens)
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Química - PPGQCâmpus São Carlos, 2017-09-29)
Acetylcholinesterase (AChE) (EC 3.1.1.7) is the enzyme responsible for catalyzing the hydrolysis of the neurotransmitter acetylcholine leading to the release of acetate and choline. In insects, acetylcholine is one of the ...
Síntese de complexos de Ru(II) luminescentes: aplicações no combate à doença de Alzheimer
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Química - PPGQCâmpus São Carlos, 2021-12-17)
Alzheimer’s disease (A.D) is the most common form of dementia affecting, especially, people with advanced age. There is no cure and the existing pharmaceuticals indicated for combating A.D act by inhibition of acetylcholinesterase ...
Determinación de la actividad inhibitoria de la fracción alcaloidal de Hymenocallis sp. sobre las enzimas acetilcolinesterasa y butirilcolinesterasa.
(Escuela Superior Politécnica de Chimborazo, 2020-01-23)
The purpose of this titration work was to determine the inhibitory activity of the alkaloidal fraction of Hymenocallis sp. on the enzyme’s acetylcholinesterase and butyrylcholinesterase, species belonging to the Amaryllidaceae ...
Diseño de formas farmacéuticas orales como rutas para dosificación de Bromhidrato de Galantamina
(Universidad de los AndesMaestría en Ingeniería QuímicaFacultad de IngenieríaDepartamento de Ingeniería Química y de Alimentos, 2023-05-29)
Actualmente, la enfermedad de Alzheimer (EA) es la causa más común de demencia en pacientes de la tercera edad dada su naturaleza neurodegenerativa. Es por esto, que distintos tratamientos se han diseñado con el fin de ...
Actualizaciones en el diagnóstico y tratamiento del deterioro cognitivo vascular
(Polemos, 2014-08)
Introducción: Los trastornos cognitivos de causa vascular representan un grupo de entidades de gran heterogeneidad etiológica y clínica. Objetivo: Revisar las últimas evidencias en el diagnóstico y tratamiento del deterioro ...
Participação do sistema colinérgico em déficits cognitivos no modelo animal de sobrecarga do ferro
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2009)
The present study evaluated the effects of the pharmacological stimulation of cholinergic system by using an acetylcholinesterase (AChE) inhibitor and a cholinergic muscarinic agonist on recognition memory impairment induced ...
Avaliação do efeito inibitório do composto orgânico de selênio ebselen na atividade da enzima acetilcolinesterase cerebral de ratos in vitro
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2015-02-27)
Acetylcholinesterase (AChE) is an important regulatory enzyme that modulates cholinergic synapses by hydrolysis of acetylcholine (ACh), a neurotransmitter involved in many biological processes, especially in memory and ...
Exploring weak intermolecular interactions in two bis-1,3,4-oxadiazoles derivatives: A combined X-ray diffraction, Hirshfeld surface analysis and theoretical studies
(Elsevier Science, 2021-05)
Two new bis-1,3,4-oxadiazole derivatives have been synthesized and characterized. The crystal structure of both compounds were solved by single crystal X-ray diffraction analysis and a detailed quantitative analysis of the ...