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Characterization of alpha X I-domain binding to Thy-1
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005-06-03)
The β 2 integrins are found exclusively in leukocytes and they are composed of a common β chain, CD18, and one of four unique α chains, CD11a (α L subunit), CD11b (α M subunit), CD11c (α ...
Evaluation of the biological activity of the disintegrin-like and cysteine-rich domains of Bothropasin, a metalloproteinase from Bothrops jararaca
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Química - PPGQCâmpus São Carlos, 2021-05-17)
Bothropasin is a 48kDa hemorrhagic class III Snake Venom Metalloproteinase (SVMP). As a multi-domain protein, it contains catalytic metalloproteinase (M), disintegrin-like (D), and cysteine rich domains (C). Integrins ...
The integrity of the α-helical domain of intestinal fatty acid binding protein is essential for the collision-mediated transfer of fatty acids to phospholipid membranes
(Elsevier Science, 2008-04)
Intestinal FABP (IFABP) and liver FABP (LFABP), homologous proteins expressed at high levels in intestinal absorptive cells, employ markedly different mechanisms of fatty acid transfer to acceptor model membranes. Transfer ...
A reliable ex vivo invasion assay of human reticulocytes by Plasmodium vivax
(Amer Soc HematologyWashingtonEUA, 2011)
Computer-aided design of a novel ligand for retinoic acid receptor in cancer chemotherapy
(Wiley-Blackwell, 2005-05-05)
The isotypes of RAR and RXR are retinoic acid and retinoid X acid receptors, respectively, whose ligand-binding domain contains the ligand-dependent activation function, with distinct pharmacological targets for retinoids, ...
Computer-aided design of a novel ligand for retinoic acid receptor in cancer chemotherapy
(Wiley-Blackwell, 2005-05-05)
The isotypes of RAR and RXR are retinoic acid and retinoid X acid receptors, respectively, whose ligand-binding domain contains the ligand-dependent activation function, with distinct pharmacological targets for retinoids, ...
An integrated computational analysis of the structure, dynamics, and ligand binding interactions of the human galectin network
(American Chemical Society, 2011-08)
Galectins, a family of evolutionarily conserved animal lectins, have been shown to modulate signaling processes leading to inflammation, apoptosis, immunoregulation, and angiogenesis through their ability to interact with ...
The Caenorhabditis elegans DAF-12 nuclear receptor: Structure, dynamics, and interaction with ligands
(Wiley-liss, Div John Wiley & Sons Inc, 2012-07)
A structure for the ligand binding domain (LBD) of the DAF-12 receptor from Caenorhabditis elegans was obtained from the X-ray crystal structure of the receptor LBD from Strongyloides stercoralis bound to (25R)-Δ7-dafachronic ...
Alternative splicing of a receptor Intracellular domain yields different ectodomain conformations, enabling Isoform-Selective Functional Ligands
(Bellwether Publ Ltd, 2020-08)
Events at a receptor ectodomain affect the intracellular domain conformation, activating signal transduction (out-to-in conformational effects). We investigated there verse direction (in-to-out) where the intracellular ...