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Golimumab in patients with active rheumatoid arthritis despite methotrexate therapy: 52-week results of the GO-FORWARD study
(2010)
Objective: To evaluate the efficacy and safety of golimumab to 52 weeks in patients with active rheumatoid arthritis despite methotrexate. Methods: Patients were randomly assigned to receive placebo plus methotrexate (group ...
Rheumatoid arthritis in latin americans enriched for amerindian ancestry is associated with loci in chromosomes 1, 12, and 13, and the HLA Class II region
(2013)
Objective To identify susceptibility loci for rheumatoid arthritis (RA) in Latin American individuals with admixed European and Amerindian genetic ancestry. Methods Genotyping was performed in 1,475 patients with RA and ...
Changes in Rab3D expression and distribution in the acini of Sjögren's syndrome patients are associated with loss of cell polarity and secretory dysfunction
(2011)
Objective Oral and ocular dryness are frequent and serious symptoms of Sjögren's syndrome (SS) that reflect problems in secretion due to glandular dysfunction. Exocytosis, an important process in the secretory pathway, ...
Tumour necrosis factor (TNF)α -308 G/G promoter polymorphism and TNFα levels correlate with a better response to adalimumab in patients with rheumatoid arthritis
(2006)
Objective: To investigate the influence of -308 tumour necrosis factor-α (TNFα) promoter polymorphism and circulating TNFα levels in the clinical response to adalimumab treatment in patients with rheumatoid arthritis (RA). ...
Blocking of p38 and transforming growth factor β receptor pathways impairs the ability of tolerogenic dendritic cells to suppress murine arthritis
(2013)
Objective Dendritic cells (DCs) modulated with lipopolysaccharide (LPS) are able to reduce inflammation when therapeutically administered into mice with collagen-induced arthritis (CIA). The aim of this study was to uncover ...
Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populations
(2012)
Objective American Indian-Europeans, Asians, and African Americans have an excess morbidity from systemic lupus erythematosus (SLE) and a higher prevalence of lupus nephritis than do Caucasians. The aim of this study was ...
A randomised phase IIb study of mavrilimumab, a novel GM-CSF receptor alpha monoclonal antibody, in the treatment of rheumatoid arthritis
(BMJ Publishing Group, 2017)
Objectives: Despite the therapeutic value of current rheumatoid arthritis (RA) treatments, agents with alternative modes of action are required. Mavrilimumab, a fully human monoclonal antibody targeting the granulocyte-macrophage ...
Reduced sulfation of MUC5B is linked to xerostomia in patients with Sjögren syndrome
(2008)
Objectives: MUC5B contains sulfated and sialylated
oligosaccharides that sequester water required for
moisturising the oral mucosa. Xerostomia, in patients with
Sjo¨gren syndrome, is generally associated with ...
Screening of proteins related to the immunological checkpoint Lymphocyte activation gene-3 (LAG-3) through the BioID method
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2018)
Screening of proteins related to the immunological checkpoint lymphocyte activation gene-3 (lag-3) through the BioID method
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2019)