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Analysis of agonist and antagonist effects on thyroid hormone receptor conformation by hydrogen/deuterium exchange
(2011-01-01)
Thyroid hormone receptors (TRs) are ligand-gated transcription factors with critical roles in development and metabolism. Although x-ray structures of TR ligand-binding domains (LBDs) with agonists are available, comparable ...
Analysis of agonist and antagonist effects on thyroid hormone receptor conformation by hydrogen/deuterium exchange
(2011-01-01)
Thyroid hormone receptors (TRs) are ligand-gated transcription factors with critical roles in development and metabolism. Although x-ray structures of TR ligand-binding domains (LBDs) with agonists are available, comparable ...
Advances in drug design based on the amino acid approach: Taurine analogues for the treatment of CNS diseases
(2012-10-23)
Amino acids are well known to be an important class of compounds for the maintenance of body homeostasis and their deficit, even for the polar neuroactive aminoacids, can be controlled by supplementation. However, for the ...
Advances in drug design based on the amino acid approach: Taurine analogues for the treatment of CNS diseases
(2012-10-23)
Amino acids are well known to be an important class of compounds for the maintenance of body homeostasis and their deficit, even for the polar neuroactive aminoacids, can be controlled by supplementation. However, for the ...
Methodologies QSAR/QSPR/QSTR: Current state and perspectives
(Nova Science Publishers, Inc., 2008-08)
The structure-properties relationships have since long been considered a vital component of drug discovery and development, providing significant insights into the role of molecular properties in the biological activity ...
Multiple binding sites in the nicotinic acetylcholine receptors: an opportunity for polypharmacolgy
(2015)
For decades, the development of selective compounds has been the main goal for chemists and biologists involved in drug discovery. However, diverse lines of evidence indicate that polypharmacological agents, i.e. those ...