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Progression of chromosomal damage induced by etoposide in G2 phase in a DNA-PKcs deficient context
(Springer, 2015-12)
Etoposide (ETO), a drug used for the treatment of human tumors, is associated with the development of secondary malignancies. Recently, therapeutic strategies have incorporated chemosensitizing agents to improve the tumoral ...
New insights into structural, electronic, reactivity, spectroscopic and pharmacological properties of Bergenin: Experimental, DFT calculations, MD and docking simulations
(2021-05-15)
Bergenin is a polyphenol found in many medicinal plants that presents numerous activities, such as antiulcer, anti-inflammatory, antifungal, anticancer, antimicrobial, antidiabetic, antiviral and antioxidant, being, ...
Síntese, estudos estruturais e de atividades biológicas de metalopeptídeos estruturalmente derivados da toxina CcdB
(Universidade Estadual Paulista (Unesp), 2019-02-27)
O presente trabalho descreve o estudo de um mimético da proteína CcdB, o CcdBSG-2, para verificar a possibilidade de formação de um complexo metálico com o lantanídeo Térbio (III) e com o íon metálico Cobre (II), bem como ...
Planejamento estrutural, modelagem molecular e síntese de complexos de cobre (ii) como potenciais inibidores da topoisomerase ii alfa humana
(Universidade Estadual Paulista (Unesp), 2021-03-05)
O câncer é considerado uma das principais causas de morte no mundo. É compreendido por mais de cem doenças que possuem características comuns, como a rápida proliferação celular e angiogênese. Embora haja fármacos disponíveis ...
Phosphoprotein levels, MAPK activities and NF kappa B expression are affected by fisetin
(Taylor & Francis LtdAbingdonInglaterra, 2007)
Differential antigenotoxic and cytoprotective effect of amifostine in idarubicin-treated mice
(Wiley-liss, Inc, 2002-12)
In this study we evaluated the antigenotoxic and cytoprotective capabilities of WR-2721 [S-2-(3aminopropylamino)-ethylphosphorothioic acid (amifostine)] in different normal tissues of BALB/c mice treated with idarubicin ...
Effect of the anti-neoplastic drug doxorubicin on XPD-mutated DNA repair-deficient human cells
(ELSEVIER SCIENCE BV, 2010)
Doxorubicin (DOX), a member of the anthracycline group, is a widely used drug in cancer therapy. The mechanisms of DOX action include topoisomerase II-poisoning, free radical release, DNA adducts and interstrand cross-link ...
Crystal structure, DNA binding studies, nucleolytic property and topoisomerase I inhibition of zinc complex with 1,10-phenanthroline and 3-methyl-picolinic acid
(Springer, 2010-02-01)
Crystal structure analysis of the zinc complex establishes it as a distorted octahedral complex, bis(3-methylpicolinato-kappa(2) N,O)(2)(1,10-phenanthroline-kappa(2) N,N)-zinc(II) pentahydrate, [Zn(3-Me-pic)(2)(phen)]center ...