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Alternative AKT2 splicing produces protein lacking the hydrophobic motif regulatory region
(Public Library of Science, 2020-11)
Three AKT serine/threonine kinase isoforms (AKT1/AKT2/AKT3) mediate proliferation, metabolism, differentiation and anti-apoptotic signals. AKT isoforms are activated downstream of PI3-kinase and also by PI3-kinase independent ...
Alternative splicing variant of RHBDD2 is associated with cell stress response and breast cancer progression
(Spandidos Publications, 2018-08)
RHBDD2 is an intramembrane pseudoprotease member of the Rhomboid superfamily. Our previous studies in breast and colorectal cancer indicate an association between RHBDD2 overexpression and advanced tumor stages. Two ...
Identification of a novel Pfkfb1 mRNA variant in rat fetal liver
(Elsevier, 2013-02)
The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) catalyzes the synthesis and degradation of fructose-2,6-bisphosphate, a key metabolite in the glucose homeostasis. Four genes, ...
Alternative splicing of the Schistosoma mansoni gene encoding a homologue of epidermal growth factor receptor
(1992)
The complete coding DNA for a Schistosoma mansoni homologue of the epidermal growth factor receptor (SER) was characterized from cDNA clones obtained by homology to the tyrosine kinase domain of erbB. The DNA sequence ...
Biochemical and cellular characteristics of the four splice variants of protein kinase CK1 α from zebrafish (Danio rerio)
(2002)
Protein kinase CK1 (previously known as casein kinase I) conforms to a subgroup of the great protein kinase family found in eukaryotic organisms. The CK1 subgroup of vertebrates contains seven members known as α, β, γ1, ...
Desenvolvimento de uma abordagem computacional para a tradução in silico de variantes de splicing detectadas no transcriptoma humano
(2012)
Um dos mecanismos capaz de aumentar a diversidade do proteoma de eucariotos é o splicing alternativo nos pré-mRNAs. Este mecanismo celular ocorre durante a transcrição dos genes, sendo ocasionado por um ou mais dos seguintes ...
The transcription factor FBI-1 inhibits SAM68-mediated BCL-X alternative splicing and apoptosis
(Nature Publishing Group, 2014-02)
Alternative splicing (AS) is tightly coupled to transcription for the majority of human genes. However, how these two processes are linked is not well understood. Here, we unveil a direct role for the transcription factor ...
Splicing alternativo na neoplasia mamária canina: revisão sistemáticaAlternative splicing in canine mammary tumor: sistematic review
(Universidade Federal de Viçosa, 2021)