Buscar
Mostrando ítems 51-60 de 106
Neogenin1 is a Sonic Hedgehog target in medulloblastoma and is necessary for cell cycle progression
(UICC, 2014)
The canonical Sonic Hedgehog (Shh)/Gli pathway plays multiples roles during central nervous system (CNS) development. To
elucidate the molecular repertoire of Shh mediators, we have recently described novel transcriptional ...
Análise imuno-histoquímica das proteínas SHH, SMO E GLI-1 em lesões benignas do epitélio odontogênico
(BrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS ODONTOLÓGICAS, 2019-10-24)
INTRODUCTION: The odontogenic cysts and tumors represent heterogeneous groups of
lesions that affect the gnatic bones and which have not yet fully clarified pathogenesis.
Therefore, several studies have been developed ...
Mutação em NOX3 estimula a proliferação de progenitores neurais cerebelares pela ativação da via de SHH
(Universidade Federal de São Paulo (UNIFESP), 2018-12-20)
TThe cerebellum is a region of the central nervous system is responsible for motor
coordination and balance. In the embryonic period, the most populous cerebellar
neuron, the granular cells, proliferate by Sonic Hedgehog ...
Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors
(Elsevier, 2011-08)
Holoprosencephaly (HPE), a common human congenital anomaly defined by a failure to delineate the midline of the forebrain and/or midface, is associated with diminished Sonic hedgehog (SHH)-pathway activity in development ...
Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review
(The Royal Society Publishing, 2022)
Developmental signalling pathways such as Wnt/beta-catenin, Notch and Sonic hedgehog play a central role in nearly all the stages of neuronal development. The term 'embryonic' might appear to be a misnomer to several people ...
Editorial: Cell polarity: Trafficking and regulatory events that determine cell asymmetry
(Frontiers Media S.A., 2023)