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Rab39a and Rab39b display different intracellular distribution and function in sphingolipids and phospholipids transport
(Molecular Diversity Preservation International, 2019-04)
Rab GTPases define the identity and destiny of vesicles. Some of these small GTPases present isoforms that are expressed differentially along developmental stages or in a tissue-specific manner, hence comparative analysis ...
ApoER2 and Reelin are expressed in regenerating peripheral nerve and regulate Schwann cell migration by activating the Rac1 GEF protein, Tiam1
(Academic Press Inc Elsevier Science, 2015-11)
ApoER2 and its ligand Reelin participate in neuronal migration during development. Upon receptor binding, Reelin induces the proteolytic processing of ApoER2 as well as the activation of signaling pathway, including small ...
Rol de la adhesión mediada por cadherina E
(2017-02-22)
La morfogénesis de los epitelios polarizados condujo a la multicelularidad y a la evolución de los metazoos. En los animales superiores, la integridad estructural y funcional de dichos tejidos involucra a las uniones ...
The monomeric GTPase RabA2 is required for progression and maintenance of membrane integrity of infection threads during root nodule symbiosis
(Springer, 2017-04-21)
Key message: Progression of the infection canal that conducts rhizobia to the nodule primordium requires a functional Rab GTPase located in Golgi/trans-Golgi that also participate in root hair polar growth. Abstract: Common ...
Tiam1 as a signaling mediator of Nerve Growth Factor-dependent neurite outgrowth
(Public Library of Science, 2010-03)
Nerve Growth Factor (NGF)-induced neuronal differentiation requires the activation of members of the Rho family of small GTPases. However, the molecular mechanisms through which NGF regulates cytoskeletal changes and neurite ...
Rheb Promotes Cancer Cell Survival Through p27Kip1-Dependent Activation of Autophagy
(Wiley and Sons, 2016)
We previously found that the small GTPase Rheb regulates the cell-cycle inhibitor p27KIP1 (p27) in
colon cancer cells by a mTORC1-independent mechanism. However, the biological function of the
Rheb/p27 axis in cancer ...
Vesicular fractions of sunflower apoplastic fluids are associated with potential exosome marker proteins
(Elsevier Science, 2009-09-29)
Based on the presence of phospholipids in the extracellular fluids (EFs) of sunflower seeds, we have hypothesized on the existence of vesicles in the apoplastic compartment of plants. Ultracentrifugation of sunflower EF ...
Computational and in vitro Pharmacodynamics Characterization of 1A-116 Rac1 Inhibitor: Relevance of Trp56 in Its Biological Activity
(Frontiers Media, 2020-04-15)
In the last years, the development of new drugs in oncology has evolved notably. In particular, drug development has shifted from empirical screening of active cytotoxic compounds to molecularly targeted drugs blocking ...
Involvement of SchRabGDI1 from Solanum chilense in endocytic trafficking and tolerance to salt stress
(Elsevier, 2017)
Physiological responses of plants to salinity stress requires the coordinated activation of many genes. A saltinduced
gene was isolated from roots of the wild tomato species Solanum chilense and named SchRabGDI1 because
it ...