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Streptozotocin-induced rodent models of diabetes: Protocol comparisons
(2014-04-01)
Type 1 and type 2 diabetes mellitus (DM) are characterized by hyperglycemia, due to lost or damaged insulin-producing β-cells within the pancreatic islets of Langerhans. Rodent models of DM result in hyperglycemia, arising ...
Obesity and impairment of pancreatic beta-cellfunction in early adulthood, independent of obesity age of onset: The Santiago Longitudinal Study
(Wiley, 2020)
Aim: We investigated the relation of time of onset and length of obesity with biomarkers of beta-cell function in early adulthood in an infancy cohort.
Material and methods: In 1039 23-year-olds, body-mass index (BMI) ...
Targeting REG3β limits pancreatic ductal adenocarcinoma progression through CTGF downregulation
(Elsevier Ireland, 2021-11)
The crosstalk between the transformed tumoral cells and their microenvironment is a key aspect for pancreatic ductal adenocarcinoma (PDAC) progression. This molecular dialog is intensively studied because it may result in ...