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Molecular Modeling Suggests Cruzain Specificity for Peptide Primaquine Prodrugs
(Bentham Science Publ Ltd, 2014)
Advances in prodrug design
(2014)
Synthesis and evaluation of a pyrazinoic acid prodrug in Mycobacterium tuberculosis
(Elsevier B.V., 2015)
Potential tuberculostatic agent: Micelle-forming pyrazinamide prodrug
(Wiley-Blackwell, 2014)
Synthesis and evaluation of a pyrazinoic acid prodrug in Mycobacterium tuberculosis
(Elsevier B.V., 2014-09-01)
Tuberculosis (TB) is a disease caused mainly by infection of Mycobacterium tuberculosis affecting more than ten million people around the world. Despite TB can be treated, the rise of MDR-TB and XDR-TB cases put the disease ...
Prodrugs for the treatment of neglected diseases
(Molecular Diversity Preservation Int, 2008-03-01)
Recently, World Health Organization ( WHO) and Medicins San Frontieres (MSF) proposed a classification of diseases as global, neglected and extremely neglected. Global diseases, such as cancer, cardiovascular and mental ...
Preparation of polymeric micelles for use as carriers of tuberculostatic drugs
(Pharmacotherapy Group, 2014)
Synthesis and pharmaceutical properties of N-acyloxymethyl prodrugs of Allop with potential anti-trypanosomal activity
(Taylor, 2016-01)
We report herein the synthesis, and the physicochemical and pharmacokinetic properties of N-acyloxymethyl prodrugs of allopurinol (Allop) (2a-f). Allop is a compound with activity against Trypanosoma cruzi, a causative ...