Advances in prodrug design
Mini-Reviews in Medicinal Chemistry, v. 5, n. 10, p. 893-914, 2005.
Távora de Albuquerque Silva, Antonio
Chin, Chung Man
Castro, Lúcia Fioravanti
Carvalho Güido, Rafael Victorio
Ferreira, Elizabeth Igne
The background of prodrug design is presented herein as the basis for introducing new and advanced latent systems, taking into account mainly the versatility of polymers and other macromolecules as carriers. PDEPT (Polymer-Directed Enzyme Prodrug Therapy); PELT (Polymer-Enzyme Liposome Therapy); CDS (Chemical Delivery System); ADEPT(Antibody-Directed Enzyme Prodrug Therapy); GDEPT/VDEPT (Gene-Directed Enzyme Prodrug Therapy/Virus-Directed Enzyme Prodrug Therapy); ODDS (Osteotropic Drug Delivery System) and LEAPT (Lectin-directed enzyme-activated prodrug therapy) are briefly described and some examples are given. © 2005 Bentham Science Publishers Ltd.
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Universidade Estadual Paulista (UNESP); Universidade de São Paulo (USP) (2005-10-01)The background of prodrug design is presented herein as the basis for introducing new and advanced latent systems, taking into account mainly the versatility of polymers and other macromolecules as carriers. PDEPT ...
Nassute, José Carlos; Longo, Maria do Carmo; Menegon, Renato Farina; Ribeiro, Yoko Asakura; Chin, Chung Man
Universidade Estadual Paulista (UNESP); Faculdade de Ciencias Farmaceuticas (2002-12-01)The PDC-70 polymeric prodrug derived from the diclofenac has shown antiedema activity when administered through intramuscular route in rats. Besides that it has produced superior activity when compared to the diclofenac ...