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Neuroprotective effect of TNFα against the β-amyloid neurotoxicity mediated by CDK5 kinase
(Elsevier B.V., 2006-10-21)
The tumor necrosis factor alpha (TNFα) plays a dual role in producing either neurodegeneration or neuroprotection in the central nervous
system. Despite that TNFα was initially described as a cell death inductor, ...
On the role of endogenous neurotoxins and neuroprotection in Parkinson's disease
(Medknow Publications & Media Pvt, 2017)
For 50 years ago was introduced L-3,4-dihydroxyphenylalanine (L-dopa) in Parkinson's disease treatment and during this significant advances has been done but what trigger the degeneration of the nigrostriatal system remain ...
Neuroprotective Effect of a New 7,8-Dihydroxycoumarin-Based Fe2+/Cu2+ Chelator in Cell and Animal Models of Parkinson’s Disease
(American Chemical Society, 2017)
© 2016 American Chemical Society.Disturbed iron homeostasis, often coupled to mitochondrial dysfunction, plays an important role in the progression of common neurodegenerative diseases such as Parkinson’s disease (PD). ...
Palmitoylethanolamide ameliorates hippocampal damage and behavioral dysfunction after perinatal asphyxia in the immature rat brain
(Frontiers Media S.A., 2018-03)
Perinatal asphyxia (PA) is an obstetric complication associated with an impaired gas exchange. This health problem continues to be a determinant of neonatal mortality and neurodevelopmental disorders. Palmitoylethanolamide ...
Minocycline benefits negative symptoms in early schizophrenia: a randomised double-blind placebo-controlled clinical trial in patients on standard treatment
(SAGE PUBLICATIONS LTDLONDON, 2012)
The onset and early course of schizophrenia is associated with subtle loss of grey matter which may be responsible for the evolution and persistence of symptoms such as apathy, emotional blunting, and social withdrawal. ...
Give Progesterone a chance
(Shenyang Editorial Dept Neural Regeneration Res, 2014-08)
There is currently no standard pharmacological treatment for spinal cord injury. Here, we suggest that progesterone, a steroid hormone, may be a promising therapeutical candidate as it is already for traumatic brain injury, ...
Glial modulation by N-acylethanolamides in brain injury and neurodegeneration
(Frontiers Media S.A., 2016-04)
Neuroinflammation involves the activation of glial cells and represents a key element in normal aging and pathophysiology of brain damage. N-acylethanolamides (NAEs), naturally occurring amides, are known for their ...