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Chronic inflammatory demyelinating polyneuropathy as an autoimmune disease
Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disease characterized by neurological symptoms and signs of progressive weakness, paresthesias, and sensory dysfunction. Other symptoms include ...
Oligodendrocyte differentiation and signaling after transferrin internalization: a mechanism of action
(Elsevier, 2013-10)
Oligodendrocytes are the cells producing the myelin membrane around the axons in the central nervous system and, although apotransferrin (aTf) is required for oligodendrocyte differentiation, the underlying mechanisms are ...
Papel dos autoanticorpos contra proteínas do sistema nervoso no desempenho cognitivo de pacientes com artrite reumatoide
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2016)
Nerve degeneration is prevented by a single intraneural apotransferrin injection into colchicines injured sciatic nerves in the rat
(Elsevier Science, 2006-01)
In this work, we have immunohistochemically analyzed the effects of single injections of apotransferrin (aTf) on the expression of myelin (myelin basic proteins [MBPs]) and axonal (protein gene product 9.5 [PGP 9.5] and ...
Extracellular Galectin-3 Induces Accelerated Oligodendroglial Differentiation Through Changes in Signaling Pathways and Cytoskeleton Dynamics
(Humana Press, 2019-01)
Galectin-3 (Gal-3) is a chimeric protein structurally composed of unusual tandem repeats of proline and short glycine-rich segments fused onto a carbohydrate recognition domain. Our studies have previously demonstrated ...
Substrate specificity of human kallikrein 6 - Salt and glycosaminoglycan activation effects
(Amer Soc Biochemistry Molecular Biology Inc, 2006-02-10)
Human kallikrein 6 ( hK6) is abundantly expressed in the central nervous system and is implicated in demyelinating disease. This study provided biochemical data about the substrate specificity and activation of hK6 by ...
Enriched environment protects the optic nerve from early diabetes-induced damage in adult rats
(Public Library Of Science, 2015-08)
Diabetic retinopathy is a leading cause of reduced visual acuity and acquired blindness. Axoglial alterations of the distal (close to the chiasm) optic nerve (ON) could be the first structural change of the visual pathway ...
Decreased production of TNF-alpha by lymph node cells indicates experimental autoimmune encephalomyelitis remission in Lewis rats
(Instituto Oswaldo Cruz, Ministério da Saúde, 2010-05-01)
Experimental autoimmune encephalomyelitis (EAE) is mediated by CD4+ Th1 cells that mainly secrete IFN-γ and TNF-α, important cytokines in the pathophysiology of the disease. Spontaneous remission is, in part, attributed ...
Decreased production of TNF-alpha by lymph node cells indicates experimental autoimmune encephalomyelitis remission in Lewis rats
(Instituto Oswaldo Cruz, Ministério da Saúde, 2010-05-01)
Experimental autoimmune encephalomyelitis (EAE) is mediated by CD4+ Th1 cells that mainly secrete IFN-γ and TNF-α, important cytokines in the pathophysiology of the disease. Spontaneous remission is, in part, attributed ...