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Caspase-1 is involved in the genesis of inflammatory hypernociception by contributing to peripheral IL-1 beta maturation
(BIOMED CENTRAL LTD, 2010)
Background: Caspase-1 is a cysteine protease responsible for the processing and secretion of IL-1 beta and IL-18, which are closely related to the induction of inflammation. However, limited evidence addresses the participation ...
Interleukin-6 deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease.
(American Society for Microbiology, 2015)
B Lymphocyte-Induced Maturation Protein-1 Contributes to Intestinal Mucosa Homeostasis by Limiting the Number of IL-17-Producing CD4(+) T Cells
(AMER ASSOC IMMUNOLOGISTSBETHESDA, 2012)
The transcription factor B lymphocyte induced maturation protein-1 (Blimp-1) plays important roles in embryonic development and immunity. Blimp-1 is required for the differentiation of plasma cells, and mice with T cell ...
Chlorella vulgaris restores bone marrow cellularity and cytokine production in lead-exposed mice
(Pergamon-elsevier Science LtdOxfordInglaterra, 2011)
Antitumor immunotherapeutic and toxic properties of an HDL-conjugated chimeric IL-15 fusion protein
(American Association for Cancer Research, 2013-01)
Interleukin (IL)-15 effects on CD8 T and natural killer (NK) lymphocytes hold promise to treat cancer. Fusion proteins have been engineered to provide IL-15 receptor alpha (IL-15Rα) mediated trans-presentation to lymphocytes ...
Papel do IFN- e da iNOS na patogênese do dengue experimental
(Universidade Federal de Minas GeraisUFMG, 2009-06-08)
Dengue is currently the most important mosquito-borne disease that affects humans and constitutes a serious world health problem. The lack of specific treatment and vaccine, and the incipient knowledge about pathogenesis ...
Acute Lung Injury in Cholinergic-Deficient Mice Supports Anti-Inflammatory Role of α7 Nicotinic Acetylcholine Receptor
(Nicola Scichilone, 2021-07)
Abstract: (1) Background: The lung cholinergic pathway is important for controlling pulmonary inflammation in acute lung injury, a condition that is characterized by a sudden onset and intense inflammation. This study ...
Imunomodulação da diabetes tipo 1 em modelos murinos: efeitos decorrentes da administração oral de linhagens de Lactococcus lactis carreadoras de plasmídeos vacinais
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em GenéticaUFMG, 2021-11-10)
Type 1 diabetes (T1D) is an autoimmune disease that culminates in beta cell destruction in the
pancreas and, subsequently, deficiency in insulin production. Cytokines play a crucial role in
the development of diabetes, ...