Article

Interleukin-6 deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease.

Registro en:
TITUS, R. G. et al. Interleukin-6 deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease. Infection and Immunity, v. 69, n. 8, p. 5189-5192, 2001.
0104-5695
10.1128/IAI.69.8.5189–5192.2001
Autor
Titus, Richard G
Dekrey, Gregory K
Morris, Robin V
Soares, Milena Botelho Pereira
Institución
Resumen
Since interleukin-6 (IL-6) may promote Th2 responses, we infected BALB IL-6-deficient (IL-6(-/-)) mice with Leishmania major. There was not a significant difference between the courses of infection (lesion size and parasite burden) in IL-6(-/-) and wild-type mice, but IL-6(-/-) mice expressed lower levels of Th2- and Th1-associated cytokines.
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