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The kinetic properties of liver glucokinase and its function in glucose physiology as a model for the comprehensive study of enzymes' kinetic parameters and reversible inhibitors
(John Wiley & Sons Inc, 2000-12)
Glucokinase is a key enzyme in carbohydrate metabolism in mammals. Particularly relevant is the involvement of the liver enzyme for the maintenance of blood glucose concentrations. In playing this key role, the occurrence ...
Hallazgo de una nueva mutación en una familia chilena con diabetes monogénica. Caso clínico
(Sociedad Medica de Santiago, 2018)
We report a 21 years old woman, without offspring, with diabetes mellitus
diagnosed at 17 years of age, without ketosis or weight loss. Her body mass index
was 18 kg/m2. Her C peptide was normal (2.3 ng/ml) and diabetes ...
Genetic and clinical characteristics of maturity-onset diabetes of the young
(Blackwell Publishing, 2005-07-01)
Genetic factors play an important role in various forms of diabetes mellitus (DM), but inheritance is complex and interacts with environmental factors. Although in most cases type 2 DM (T2DM) and T1DM are polygenic disorders, ...
Dissecting the functional roles of the conserved nxxe and hxe motifs of the adp-dependent glucokinase from thermococcus litoralis
(2015)
The activity of the ADP-dependent glucokinase from Thermococcus litoralis (TIGK) relies on the highly conserved motifs NXXE (i.e. Asn-Xaa-Xaa-Glu) and HXE (i.e. His-Xaa-Glu). Site-directed mutagenesis of residues Glu279 ...
Dynamic Localization of Glucokinase and Its Regulatory Protein in Hypothalamic Tanycytes.
Glucokinase (GK), the hexokinase involved in glucose sensing in pancreatic β cells, is also expressed in hypothalamic tanycytes, which cover the ventricular walls of the basal hypothalamus and are implicated in an indirect ...
Adenovirus-mediated suppression of hypothalamic glucokinase affects feeding behavior.
Glucokinase (GK), the hexokinase involved in glucosensing in pancreatic β-cells, is also expressed in arcuate nucleus (AN) neurons and hypothalamic tanycytes, the cells that surround the basal third ventricle (3V). Several ...
Diabetes mellitus caused by a mutation of glucokinase gene. Report of an affected family
(2017)
Maturity-Onset Diabetes of the Young (MODY) refers to a heterogeneous group of monogenic diabetes. Unlike other types of MODY characterized by genetic defects in transcription factors, MODY 2 is triggered by metabolic ...
Kinetic studies of rat liver hexokinase D ('glucokinase') in non-co-operative conditions show an ordered mechanism with MgADP as the last product to be released
(2003)
The kinetic mechanism of rat liver hexokinase D (‘ glucokinase’)
was studied under non-co-operative conditions with 2-
deoxyglucose as substrate, chosen to avoid uncertainties derived
from the co-operativity observed ...