Buscar
Mostrando ítems 41-50 de 177
β8 integrin expression and activation of tgf-β by intestinal dendritic cells are determined by both tissue microenvironment and cell lineage
(Facultad de Ciencias, 2016)
Activation of TGF-β by dendritic cells (DCs) expressing αvβ8 integrin is essential for the generation of intestinal regulatory T cells (Tregs) that in turn promote tolerance to intestinal Ags. We have recently shown that ...
VIP Promotes Recruitment of Tregs to the Uterine–Placental Interface During the Peri-Implantation Period to Sustain a Tolerogenic Microenvironment
(Frontiers Media S.A., 2020-01)
Uterine receptivity and embryo implantation are two main processes that need a finely regulated balance between pro-inflammatory and tolerogenic mediators to allow a successful pregnancy. The neuroimmune peptide vasoactive ...
Targeting galectin-1 inhibits pancreatic cancer progression by modulating tumor–stroma crosstalk
(National Academy of Sciences, 2018-04)
Pancreatic ductal adenocarcinoma (PDA) remains one of the most lethal tumor types, with extremely low survival rates due to late diagnosis and resistance to standard therapies. A more comprehensive understanding of the ...
Control of the inflammatory response during pregnancy: Potential role of VIP as a regulatory peptide
(Wiley, 2019-02)
A network of cell–cell communications through contact and soluble factors supports the maternal–placental interaction and provides a suitable environment for fetal growth. Trophoblast cells take center stage at these loops: ...
Therapeutic blockade of Foxp3 in experimental breast cancer models
(Springer, 2017-11)
Purpose: Regulatory T cells (Tregs) impair the clinical benefit of cancer immunotherapy. To optimize the antitumor efficacy of therapeutic dendritic cell (DC) vaccines, we aimed to inhibit Foxp3, a transcription factor ...
Study of galectins in tumor immunity: strategies and methods.
(Springer, 2015-01)
During the past decade, a better understanding of the cellular and molecular mechanisms underlying tumor immunity has provided the appropriate framework for the development of therapeutic strategies for cancer immunotherapy. ...
Mecanismos de supresión de las células T reguladoras (Treg)
(Gaceta Médica de México. 2013;149 630, 2015)
Antitumoral ans inmunomodulatory role for histamine in breast cancer
(Fundación Revista Medicina, 2019)
It is well known that histamine is a key regulator of inmune cell functions and it also modulates cancer cell proliferation. The aim of this work was to investigate the effect of histamine and its H4 receptor (H4R) agonist ...