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Grab recruitment by Rab27A-Rabphilin3a triggers Rab3A activation in human sperm exocytosis
(Elsevier Science, 2019-04)
Sperm must undergo the regulated exocytosis of its dense core granule (the acrosome reaction, AR) to fertilize the egg. We have previously described that Rabs3 and 27 are organized in a RabGEF cascade within the signaling ...
Decrease of Rab11 prevents the correct dendritic arborization, synaptic plasticity and spatial memory formation
(Elsevier Science, 2020-09)
Emerging evidence shows that Rab11 recycling endosomes (REs Rab11) are essential for several neuronal processes, including the proper functioning of growth cones, synapse architecture regulation and neuronal migration. ...
Tuba activates cdc42 during neuronal polarization downstream of the small gtpase rab8a
(Society for Neuroscience, 2021-02)
The acquisition of neuronal polarity is a complex molecular process that depends on changes in cytoskeletal dynamics and directed membrane traffic, regulated by the Rho and Rab families of small GTPases, respectively. ...
Rab-mediated trafficking role in neurite formation
(Wiley Blackwell Publishing, Inc, 2014-04)
Neuronal cells are characterized by the presence of two confined domains, which are different in their cellular properties, biochemical functions and molecular identity. The generation of asymmetric domains in neurons ...
Differential requirement of Rab22a for the recruitment of ER-derived proteins to phagosomes and endosomes in dendritic cells
(Taylor & Francis, 2017-11)
The recruitment of endoplasmic reticulum (ER) components to dendritic cell (DC) phagosomes and endosomes is a crucial event to achieve efficient cross-presentation of exogenous antigens. We have previously identified the ...
RabGTPase-mediated trafficking: Its role in neurite formation
(Wiley Blackwell Publishing, Inc, 2014-03)
Neuronal cells are characterized by the presence of two confined domains, which are different in their cellular properties, biochemical functions and molecular identity. The generation of asymmetric domains in neurons ...
Nuclear accumulation of beta-catenin is associated with endosomal sequestration of the destruction complex and increased activation of Rab5 in oral dysplasia
(Wiley, 2020)
Potentially malignant lesions, commonly referred to as dysplasia, are associated with malignant transformation by mechanisms that remain unclear. We recently reported that increased Wnt secretion promotes the nuclear ...