info:eu-repo/semantics/article
Decrease of Rab11 prevents the correct dendritic arborization, synaptic plasticity and spatial memory formation
Fecha
2020-09Registro en:
Siri, Sebastian Omar; Rozés Salvador, María Victoria; Artur de la Villarmois, Emilce; Ghersi, Marisa Soledad; Quassollo Infanzon, Gonzalo Emiliano; et al.; Decrease of Rab11 prevents the correct dendritic arborization, synaptic plasticity and spatial memory formation; Elsevier Science; Biochimica et Biophysica Acta-Molecular Cell Research; 1867; 9; 9-2020; 1-13
0167-4889
CONICET Digital
CONICET
Autor
Siri, Sebastian Omar
Rozés Salvador, María Victoria
Artur de la Villarmois, Emilce
Ghersi, Marisa Soledad
Quassollo Infanzon, Gonzalo Emiliano
Perez, Mariela Fernanda
Conde, Cecilia Beatriz
Resumen
Emerging evidence shows that Rab11 recycling endosomes (REs Rab11) are essential for several neuronal processes, including the proper functioning of growth cones, synapse architecture regulation and neuronal migration. However, several aspects of REs Rab11 remain unclear, such as its sub-cellular distribution across neuronal development, contribution to dendritic tree organization and its consequences in memory formation. In this work we show a spatio-temporal correlation between the endogenous localization of REs Rab11 and developmental stage of neurons. Furthermore, Rab11-suppressed neurons showed an increase on dendritic branching (without altering total dendritic length) and misdistribution of dendritic proteins in cultured neurons. In addition, suppression of Rab11 in adult rat brains in vivo (by expressing shRab11 through lentiviral infection), showed a decrease on both the sensitivity to induce long-term potentiation and hippocampal-dependent memory acquisition. Taken together, our results suggest that REs Rab11 expression is required for a proper dendritic architecture and branching, controlling key aspects of synaptic plasticity and spatial memory formation.