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Neonicotinic analogues: Selective antagonists for α4β2 nicotinic acetylcholine receptors
(2013)
Nicotine is an agonist of nicotinic acetylcholine receptors (nAChRs) that has been extensively used as a template for the synthesis of α4β2-preferring nAChRs. Here, we used the N-methyl-pyrrolidine moiety of nicotine to ...
Chaperoning a7 neuronal nicotinic acetylcholine receptors
(Elsevier, 2012-03)
The α7 subtype of nicotinic acetylcholine receptors (AChRs) is one of the most abundant members of the Cysloop family of receptors present in the central nervous system. It participates in various physiological processes ...
Corticosterone affects the differentiation of a neuronal cerebral cortex-derived cell line through modulation of the nicotinic acetylcholine receptor
(Elsevier, 2014-08-22)
Chronic exposure to stress hormones has an impact on brain structures relevant to cognition. Nicotinic acetylcholine receptors (AChRs) are involved in numerous cognitive processes including learning and memory formation. ...
Nicotonic and muscarinic components in acetylcholine stimulation of porcine adrenal medullary cells
(1997)
Adrenal medullary chromaffin cells secrete catecholamines (CA) in response to cholinergic receptor activation by acetylcholine (ACh) released from splacnic nerve terminals. In cultured bovine chromaffin cells nicotinic ...
Modulation of hypercapnic respiratory response by cholinergic transmission in the commissural nucleus of the solitary tract
(2020-01-01)
The nucleus of the solitary tract (NTS) is an important area of the brainstem that receives and integrates afferent cardiorespiratory sensorial information, including those from arterial chemoreceptors and baroreceptors. ...
Nicotinic acetylcholine receptors at the single-channel level
(Wiley Blackwell Publishing, Inc, 2018-06)
Over the past four decades, the patch clamp technique and nicotinic ACh (nACh) receptors have established an enduring partnership. Like all good partnerships, each partner has proven significant in its own right, while ...
Neurotransmission in the carotid body: transmitters and modulators between glomus cells and petrosal ganglion nerve terminals
(ELSEVIER SCIENCE BV, 2004-12)
The carotid body (CB) is the main arterial chemoreceptor. The most accepted model of arterial chemoreception postulates that carotid body glomus (type 1) cells are the primary receptors, which are synaptically connected ...
Neurotransmission in the carotid body: transmitters and modulators between glomus cells and petrosal ganglion nerve terminals
(ELSEVIER, 2004-12)
The carotid body (CB) is the main arterial chemoreceptor. The most accepted model of arterial chemoreception postulates that carotid body glomus (type 1) cells are the primary receptors, which are synaptically connected ...
The nicotinic acetylcholine receptor as a molecular machine for neuromuscular transmission
(Elsevier, 2018-08)
The nicotinic acetylcholine receptor (nAChR) has crucial functions at the neuromuscular junction (NMJ). It belongs to the superfamily of pentameric ligand-gated ion channels and has become the stereotype for probing ...
α7-type acetylcholine receptor localization and its modulation by nicotine and cholesterol in vascular endothelial cells
(Wiley, 2011-06)
The neuronal-type 7 nicotinic acetylcholine receptor (7AChR) is also found in various non-neural tissues, including vascular endothelium, where its peculiar ionotropic properties (high Ca2+ permeability) and its supervening ...