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Interaction of dopamine D1 with NMDA NR1 receptors in rat prefrontal cortex
(Elsevier, 2009-01)
Despite the tremendous importance of D1 and NMDA receptors to cognition (working memory, executive functions) and synaptic plasticity in the prefrontal cortex (PFC), little is known about the molecular mechanisms underlying ...
Role of PFC during retrieval of recognition memory in rodents
(Elsevier, 2014-09)
One of the challenges for memory researches is the study of the neurobiology of episodic memory which is defined by the integration of all the different components of experiences that support the conscious recollection of ...
Medial prefrontal cortex dopamine controls the persistent storage of aversive memories
(Frontiers, 2014-11)
Medial prefrontal cortex (mPFC) is essential for initial memory processing and expression but its involvement in persistent memory storage has seldom been studied. Using the hippocampus dependent inhibitory avoidance ...
The effects of single-dose injections of modafinil and methamphetamine on epigenetic and functional markers in the mouse medial prefrontal cortex: potential role of dopamine receptors
(Pergamon-Elsevier Science Ltd, 2019-03)
METH use causes neuroadaptations that negatively impact the prefrontal cortex (PFC) leading to addiction and associated cognitive decline in animals and humans. In contrast, modafinil enhances cognition by increasing PFC ...
Differential behavioral profile induced by the injection of dipotassium chlorazepate within brain areas that project to the nucleus accumbens septi.
(Polish Acad Sciences Inst Pharmacology, 2013-08)
The effect of the agonism on g-aminobutyric acid (GABA) receptors was studied within medial prefrontal cortex (mPFC), amygdala (AMY) and ventral hipocampus (VH) in the plus-maze test in male rats bilaterally cannulated. ...
Orexin 1 and 2 Receptors in the Prelimbic Cortex Modulate Threat Valuation
(2021-08-01)
The ability to distinguish between threatening (repulsors), neutral and appetitive stimuli (attractors) stimuli is essential for survival. The orexinergic neurons of hypothalamus send projections to the limbic structures, ...
Methamphetamine blunts Ca2+ currents and excitatory synaptic transmission through D1/5 receptor-mediated mechanisms in the mouse medial prefrontal cortex
(Wiley Blackwell Publishing, Inc, 2016-05)
Psychostimulant addiction is associated with dysfunctions in frontal cortex. Previous data demonstrated that repeated exposure to methamphetamine (METH) can alter prefrontal cortex (PFC)-dependent functions. Here, we show ...
Interneuron NMDA receptor ablation induces hippocampus-prefrontal cortex functional hypoconnectivity after adolescence in a mouse model of schizophrenia
(Society for Neuroscience, 2020-04)
Although the etiology of schizophrenia is still unknown, it is accepted to be a neurodevelopmental disorder that results from the interaction of genetic vulnerabilities and environmental insults. Although schizophrenia’s ...
Differential roles of prelimbic and infralimbic cholinergic neurotransmissions in control of cardiovascular responses to restraint stress in rats
(2022-04-01)
Previous studies showed a prominent role of the medial prefrontal cortex (mPFC), especially the prelimbic (PL) and infralimbic (IL) subregions, in behavioral and physiological responses to stressful stimuli. Nevertheless, ...
O bloqueio dos receptores glicocorticóides da região infralímbica do córtex pré-frontal medial facilita a aquisição, mas não a consolidação da memória de camundongos submetidos ao protocolo de teste e reteste no labirinto em cruz elevado
(Universidade Federal de São CarlosUFSCarPrograma Interinstitucional de Pós-Graduação em Ciências Fisiológicas - PIPGCFCâmpus São Carlos, 2018-09-21)
A single experience (test) in the elevated plus maze (EPM) increases the avoidance of open arms and impairs the anxiolytic efficacy of the midazolam benzodiazepine agonist (MDZ) in a subsequent re-esposition (retest). ...