Buscar
Mostrando ítems 41-50 de 386
A utiliza????o de inibidores de PARP na profilaxia e no tratamento do c??ncer de mama deficiente no gene BRCA1
(Instituto de Ci??ncias da Sa??de/ Universidade Federal da Bahia, 2010-09)
BRCA1 and BRCA2 mutations other than the founder alleles among Ashkenazi Jewish in the population of Argentina
(Frontiers Media SA, 2018-08)
In Ashkenazi Jewish (AJ) high risk families 3 mutations [2 in BRCA1 (c. 68_69del and c.5266dup) and 1 in BRCA2 (c.5946del)] account for the majority of high risk breast and ovarian cancer cases in that ethnic group. Few ...
Spectrum of BRCA1/2 point mutations and genomic rearrangements in high-risk breast/ovarian cancer Chilean families
(2011)
The distribution of BRCA1/2 germline mutations in breast/ovarian cancer (BC/OC) families varies among different populations. In the Chilean population, there are only two reports of mutation analysis of BRCA1/2, and these ...
Spectrum of BRCA1/2 point mutations and genomic rearrangements in high-risk breast/ovarian cancer Chilean families
(2011)
The distribution of BRCA1/2 germline mutations in breast/ovarian cancer (BC/OC) families varies among different populations. In the Chilean population, there are only two reports of mutation analysis of BRCA1/2, and these ...
Hypermethylation of BRCA1 gene in meningioma in elderly males
(2018-05-01)
Background/Aim: Breast cancer 1, early onset (BRCA1) gene is expressed in the cells of the breast and other tissues, where it plays a role in cell-cycle regulation, transcription, repair of DNA double-stranded breaks, ...
BRCA1 loss induces GADD153-mediated doxorubicin resistance in prostate cancer
(American Association for Cancer Research, 2011-08)
BRCA1 plays numerous roles in the regulation of genome integrity and chemoresistance. Although BRCA1 interaction with key proteins involved in DNA repair is well known, its role as a coregulator in the transcriptional ...
Hereditary breast and ovarian cancer: assessment of point mutations and copy number variations in Brazilian patients
(BioMed CentralLondon, 2014-05)
Background
Germ line mutations in BRCA1 and BRCA2 (BRCA1/2) and other susceptibility genes have
been identified as genetic causes of hereditary breast and ovarian cancer (HBOC). To identify
the disease-causing mutations ...